Screening and elucidation of an allergic exacerbation-barrier disruption action substance in environment and food

上皮细胞包围着哺乳动物的器官和组织，而上皮细胞膜构成了细胞摄取和运输的主要屏障。紧密连接(TJ)作为限制各种物质，如病原体、毒素和过敏原的屏障，发挥着关键作用。在本研究中，我们对环境和食物中破坏屏障功能和免疫系统紊乱的化学物质进行了筛选。观察到各种环境污染物均降低了TJ的屏障功能。此外，我们观察到，用二恶英和抗原处理小鼠，可显著增加抗原特异性免疫球蛋白的产生，并呈剂量依赖关系。这些结果表明，环境和食物中的化学物质会扰乱屏障功能和免疫系统。

Epithelial cells surround mammalian organs and tissues and epithelial cell sheets constitute the principal barrier to cellular uptake and transport. The tight junction(TJ) plays a pivotal role as both a barrier to restrict various substances, such as pathogens, toxins, and allergens. In this study, we screened the chemical substances to disruption of barrier function and disturbance of immune system in environment and food. It was observed that various environmental pollutants were decreased barrier function of TJ. Furthermore, we observed that treatment of mice with dioxins and antigen results in significant elevation antigen-specific immunoglobulin production in a dose-dependent manner. There results suggest the chemical substance in environment and food dysregulates the barrier function and immune system.