Fundamental understanding of phenylpropanoid, lignin and flavonoid biosynthesis regulated by metabolon formation in grasses for precise manipulation to improve biomass utility

本研究以水稻为模型，旨在了解草类植物中苯丙素、木质素和类黄酮类生物合成酶代谢产物(蛋白质-蛋白质相互作用网络)的全球组织结构，并阐明代谢产物的形成如何控制苯丙素、木质素和类黄酮类生物合成中的代谢通道。通过电子计算机分析，已经确定了水稻木质素、类黄酮类和苯丙烷生物合成途径中所有可能的和已知的酶。拟议中的实验目前正在进行中。

The proposed research is aimed to understand the global organization of metabolons (protein-protein interaction networks) of phenylpropanoid, lignin and flavonoid biosynthetic enzymes that governs metabolite channelling and crosstalk between these pathways in grasses using rice as a model, and to elucidate how metabolon formation controls metabolic channeling in phenylpropanoid, lignin and flavonoid biosynthesis. Through in silico analysis, all the putative and known enzymes in the lignin, flavonoid and phenylpropanoid biosynthetic pathways of rice have been identified. The proposed experiments are currently ongoing.