Analysis of the effect of oxidative stress on abnormal placentation

我们检测了滋养细胞侵袭相关分子在前置胎盘尤其是植入胎盘中的表达。采用免疫组织化学方法检测正常胎盘、妊高征胎盘、前置胎盘、植入胎盘、胎盘床中硫氧还蛋白（TRX）、TLR3、TLR4、CD56、CD68、VEGF的表达。TRX在妊高征胎盘组织中的表达略高，尤其是绒毛膜和蜕膜组织。在前置胎盘和植入胎盘中，TRX几乎不表达于胎盘的所有区域，其他分子表达差异不大。TRX在前置胎盘和植入胎盘中表达减少。这可能表明氧化应激减少，因此前置胎盘先兆子痫的发生率降低。

We assesed the expression of trophoblast invasion related molecules in placenta previa, especially accreta. We immunohistochemically assessed the expressions of thioredoxin (TRX), TLR3, TLR4, CD56, CD68, VEGF in the placenta of control, PIH, placenta previa and placenta accreta, and placental bed of control and placenta accreta. TRX expression is slightly higher in PIH placenta, especially chorion and decidua. In placenta previa and accreta, TRX expression is hardly seen in all the area of placenta.There are little differences of expression in other molecules. TRX expression decreased in placenta previa and accreta. It may indicate that oxidative stress decreases andtherefore preeclampsia frequency is reduced in placenta previa.