Fabrication of novel apatite coating implant based on new concept

本研究的目的是制备羟基磷灰石（HAp）涂层钛（Ti），与等离子喷涂法制备的HAp涂层相比，羟基磷灰石（HAp）涂层与Ti基体之间具有较高的粘附强度，并且在注入后具有较长的化学稳定性。采用我们独创的方法，将工业磷酸锌涂层与水热处理混合，在钛植入体上成功制备了磷酸锌涂层。然后用适当的钙盐溶液处理磷酸锌，使其转化为HAp。所得涂层与Ti基体的结合强度为36.7±17 MPa，约为等离子喷涂法的4倍。利用大鼠骨髓细胞进行的体外骨电导率评价表明，羟基磷灰石涂层的细胞附着、增殖、分化和钙化明显高于未处理的钛涂层。因此，本研究提出的新型治疗方法对钛种植体的导通治疗有一定的指导意义。

Aim of this study is to fabricate hydroxyapatite(HAp) coating titanium(Ti) which shows high adhesivestrength between HAp coating and Ti substrate and chemically stable with time after implantation whencompared to HAp coating prepared by plasma spraying method. Zinc phosphate coating was successfullyprepared on Ti implant using our original method employing industrial zinc phosphate coating mixed withhydrothermal treatment. Subsequently the zinc phosphate could transform to HAp by treating withappropriate calcium salt solution. Adhesive strength between obtained coating and Ti substrate was 36.7 ±17 MPa which was approximately 4 times compared to that obtained by plasma spraying method. In vitroosteoconductivity evaluated using rat bone marrow cells indicated that cell attachment, proliferation,differentiation and calcification for HAp coating were significantly higher than that for non-treated Ti. Itis concluded that novel treatment proposed in this study would be useful for ostconductive treatment ofTi implant.