The study of aldosterone production machinery by angiotensin II metabolite

调节血压的醛固酮是由肾上腺皮质小球带的血管紧张素II （A-II）产生的。我们之前证明了A-II的代谢物在人肾上腺皮质癌细胞系中负调控A-II介导的醛固酮的产生。在这项研究中，我们澄清了代谢产物是血管紧张素1-7，它在A-II刺激后抑制醛固酮的产生。血管紧张素1-7在醛固酮生成中的作用是由MAS受体介导的。我们发现了一种新的通过MAS受体产生醛固酮的机制，我们的结果可能有助于抗高血压药物的新靶点。

Aldosterone which regulates blood pressure is produced by angiotensin II (A-II) in zona glomerulosa of adrenal cortex. We previously demonstrated that the metabolite of A-II negatively regulated A-II mediated aldosterone production in human adrenocortical cancer cell line. In this study, we clarified that the metabolite was angiotensin 1-7 and it inhibit aldosterone production after A-II stimulation. The function of angiotensin 1-7 on aldosterone production was mediated by MAS receptor. We showed a new aldosterone production machinery via MAS receptor and our results might be useful for new target of anti-hypertensive agents.