Foundations of a good egg: correctly transitioning from mitosis to meiosis

产生有活力的后代对于任何物种的生存都至关重要。在所有有性繁殖的物种中，这需要一种独特的细胞类型，即生殖细胞。生殖细胞经历一种特殊类型的细胞分裂，称为减数分裂，这样它们最终可以产生配子（雄性的精子和雌性的卵子）。该项目旨在发现生殖细胞如何停止标准形式的细胞分裂（称为有丝分裂），并启动减数分裂。了解正常生殖细胞发育过程中发生的所有基本过程非常重要，以便将来我们可以利用这些知识来支持农业进步、拯救濒危物种并解决不孕症和遗传病等人类问题。

Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.