Establishment of Exercise Prescription Based On Cardiac Autonomic Activity

本研究的目的是建立基于心脏自主神经系统活动（迷走神经活动阈值：VAT）的运动处方，并评估由个体VAT确定的“安全运动阈值”的有效性。我们首先开发了一种新的计算机辅助分析系统，可以通过ECG R-R间隔功率谱和心率加速-减速功率分析分别直接评估心脏自主神经活动，特别是副交感神经（迷走神经）活动。对51名男大学生和13名充血性心力衰竭患者进行了增量运动负荷试验。结果表明，基于心脏副交感神经活动确定安全运动阈值的方法是非常有效的，甚至可以用来评估心衰患者的心肌功能。在随后的研究中，我们实际上将这一安全运动阈值用于obe的运动处方，更多的女性表现出与生活方式相关疾病的高风险因素。12周的运动训练可以显著改善血脂、血压、体脂率和自主神经系统活动。此外，在VAT的运动干预实验表明，运动前后ET-1、儿茶酚胺和BNP水平无显著差异！然而，ANP水平在运动后显著升高（运动前：18.6±5.38 pg/ml vs运动后：44.0±24.87,P < 0.001），从而导致运动后血压显著降低（收缩压：117.6±13.7 mmHg vs 110.5±7.4,P <0.05, DBF: 78.6±6.7 vs 73.5±6.6,P <0.01）。我们的数据表明，可以根据心脏迷走神经反应来确定运动强度（VAT）。这些结果还表明，鉴于心脏压力，VAT水平的运动是安全的运动强度，并且VAT可能被推荐给包括可能具有较低心脏交感神经迷走神经活动的肥胖人群。少

The purpose of this study was to establish exercise prescription based upon cardiac autonomic nervous system activity (Vagal Activity Threshold : VAT) and to evaluate the efficacy of this "Safety Exercise Threshold" determined by individual VAT. We first developed a new computer-aided analysis system for allowing a direct evaluation of cardiac autonomic activity particularly the parasympathetic (vagal) activity by means of ECG R-R interval power spectral and heart rate acceleration-deceleration power analyses, respectively. Fifty-one male college students and 13 patients with congestive heart failure were tested during incremental exercise stress test. Results indicated that our method of determining safety exercise threshold based on cardiac parasympathetic nervous activity was quite effective and could be used to even evaluate myocardial functions of the heart failure patients. In the subsequent studies, we actually used this safety exercise threshold for exercise prescription of obe … More se women who manifested high risk factors for life-style related diseases. Twelve weeks of exercise training results in significant improvements in lipid profile, blood pressure, percent body fat, and autonomic nervous system activity. Furthermore, exercise intervention experiment at VAT indicated that ET-1, catecholamine, and BNP levels were not significantly different before and after exercise! However, ANP levels increased,significantly after exercise (pre-exercise: 18.6±5.38 pg/ml vs post-exercise: 44.0±24.87, P < 0.001), which in turn brought about a significant post-exercise reduction in the blood pressure (SBP: 117.6±13.7 mmHg vs. 110.5±7.4, P <0.05, DBF: 78.6±6.7 vs. 73.5±6.6, P <0.01). Our data suggest that it is possible to determine the exercise intensity (VAT) on the basis of cardiac vagal response. These results also suggest that exercise at VAT level is safe exercise intensity in the light of cardiac stress, and that VAT may be recommended for individuals including obese people who might possess lower cardiac sympatho-vagal activity. Less