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Development and evaluation of functional muscle electrical stimulation for individuals with limited exercise capacity

针对运动能力有限的个体的功能性肌肉电刺激的开发和评估

基本信息

批准号：
15300231
负责人：
MORITANI Toshio
金额：
$ 8万
依托单位：
The Graduate School of Human and Environmental Studies, Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

We have demonstrated that low frequency electrical stimulation (ES) of quadriceps muscles alone significantly enhanced glucose disposal rate (GDR) during euglycemic clamp. We further followed up to examine the acute metabolic effects of ES to lower extremities in comparison with voluntary cycle exercise (VE) at identical intensity. In eight male subjects lying in the supine position, both lower leg (tibialis anterior and triceps surae) and thigh (quadriceps and hamstrings) muscles were sequentially stimulated to co-contract in an isometric manner at 20Hz with a 1-s on-off duty cycle for 20min. Despite of small elevation of oxygen uptake by 7.3±0.3 ml/kg/min during ES, the blood lactate concentration was significantly increased by 3.2±0.3 mmol/l in initial period (5min) after the onset of the ES (P<0.01) whereas VE showed no such changes at identical oxygen uptake (7.5±0.3 ml/kg/min). ES also induced enhanced whole body carbohydrate oxidation as shown by the significantly higher respiratory gas exchange ratio than VE (P<0.01). These data indicated increased anaerobic glycolysis by ES. Furthermore, whole-body glucose uptake determined by GDR during euglycemic clamp demonstrated a significant increase during and after the cessation of ES for at least 90min (P<0.01). This post ES effect was significantly greater than that of post VE period (P<0.01). These results suggest that ES can substantially enhance energy consumption, carbohydrate oxidation and whole body glucose uptake at low intensity of exercise. Percutaneous ES may become therapeutic utility to enhance glucose metabolism in humans.

我们已经证明，低频电刺激（ES）的股四头肌单独显著提高葡萄糖处置率（GDR）在正糖钳。我们进一步跟踪研究了ES对下肢的急性代谢影响，并与相同强度的自愿循环运动（VE）进行了比较。8名男性受试者仰卧位，分别刺激小腿（胫骨前肌和面三头肌）和大腿（股四头肌和腘沟肌）肌肉以20Hz的等距方式以1秒的开-关工作周期共同收缩20min。血乳酸浓度在ES发作初期（5min）升高了3.2±0.3 mmol/l (P<0.01)，而在相同的摄氧量（7.5±0.3 ml/kg/min）下，VE无明显变化（P<0.01）。ES还诱导全体碳水化合物氧化，呼吸气体交换率显著高于VE （P<0.01）。这些数据表明ES增加了厌氧糖酵解。此外，正糖钳夹期间GDR测定的全身葡萄糖摄取在ES停止期间和停止后至少90min显著增加（P<0.01）。ES后效应显著大于VE后（P<0.01）。这些结果表明，ES可以显著提高低强度运动时的能量消耗、碳水化合物氧化和全身葡萄糖摄取。经皮ES可能成为促进人体葡萄糖代谢的治疗工具。