Analysis of bacterial infectious-pathogens in Japan and Asian countries.

1999年从患者体内分离到的Oranienburg沙门氏菌为VNC株，对氯化钠渗透胁迫敏感。这些菌株在小鼠身上传代后，它们对氯化钠渗透胁迫产生了抵抗力。VNC橙色沙门氏菌可能是氯化钠腌制食品的潜在危险污染物。VNC沙门氏菌对吗啡处理的小鼠有较强的致病性。吗啡处理的小鼠是VNC沙门氏菌良好的生物测定模型。我们观察了绵羊15个月的STEC分泌情况。绵羊一旦有STEC，就会维持STEC并长期分泌。我们在弗氏柠檬酸杆菌中发现了霍乱毒素B亚基与大肠杆菌LT毒素的同源物，并测定了该基因的序列。构建了幽门螺杆菌VacA的高灵敏微球ELISA检测体系，并成功地从胃溃疡患者的胃液中直接检测到了VacA。这一结果表明错误的RTPβ信号导致了胃溃疡。

Salmonella Oranienburg strains which had isolated from the patient in 1999 were VNC and sensitive to NaCl osmotic stress. After the passage of these strains in mice, they became resistant to NaCl osmotic stress. VNC Salmonella Oranienburg would be potentially dangerous contaminants of NaCl-preserved foods. VNC Salmonella showed high pathogenicity to morphine-treated mice. The morphine-treated mouse is the good bioassay model for VNC Salmonella.We investigated the secretion of STEC from the sheep for 15 months. Once a sheep had STEC, it maintained STEC and secreted it for a long time. A sheep might be important as a reservoir of STEC.We found the homologue of the B-subunit of Cholera toxin and E. coli LT toxin in Citrobacter freundii and determined the sequence of the gene.We constructed the highly sensitive bead-ELISA system for Helicovacter pylori VacA and succeeded to detect VacA directly in the gastric juice of the gastric ulcer patients.The mice deficient in RPTP β do not show mucosal damage by VacA of Helicobacter pylori. This result indicates that erroneous RPTP β signaling induced gastric ulcers.