A study on neuropathology of AIDS patients in Africa

本研究的目的是检查在坦桑尼亚达累斯萨拉姆感染人类免疫缺陷病毒（HIV）的患者的大脑神经病理学变化。从法医尸检中选择的218例患者中，78例（35.8%）被确定为HIV感染。78例HIV感染者中35例（44.9%）有神经病理改变，其中淋巴细胞性脑膜炎20例，细菌性脑膜炎3例，结核性脑脓肿4例，弓形虫性脑炎3例，隐球菌性脑膜炎2例，基底节钙化3例。本研究未发现HIV脑炎、淋巴瘤和巨细胞病毒脑炎。这些结果提供了可能的诊断可能性，以考虑在坦桑尼亚的神经症状的艾滋病毒感染患者的评价和管理的信息。

The objective of this study was to examine the neuropathological changes in the brain of patients infected with human immunodeficiency virus (HIV) in Dar es Salaam, Tanzania. HIV infection was identified in 78 (35.8%) of 218 patients selected from forensic autopsies. Neuropathological findings were observed in 35 (44.9%) of 78 HIV infected patients these include lymphocytic meningitis 20, bacterial meningitis 3, tuberculous brain abscess 4, toxoplasma encephalitis 3, cryptococcal meningitis 2, basal ganglia calcification 3. HIV encephalitis, lymphoma, and cytomegalovirus encephalitis could not be found in this study. These results provided information on the likely diagnostic possibilities to be considered in the evaluation and management of HIV infected patients with neurological symptoms in Tanzania.