Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.

1)我们发现，肾上腺髓质素是一种血管扩张剂，它的表达在低氧条件下被增强。2)我们发现，在肿瘤组织中应用肾上腺髓质素拮抗剂多肽可以通过抑制血管生成而导致肿瘤的消失。3)我们发现显性阴性的HIF-1α降低了对低血糖诱导的凋亡的抵抗力。4)我们还发现显性阴性的HIF-1α降低了胰腺癌细胞系的致瘤性。5)我们证明显性阴性的HIF-1α降低了缺氧增强的GLUT-1的表达，显性阴性的HIF-1α降低了肿瘤组织对FDG的摄取。

1)We found that the expression of adrenomedullin, which has been reported to be a vasodilater, is enhanced by hypoxia.2)We found that the administration of adrenomedullin antagonist peptides into tumor tissues induced the disappearance of tumors through the suppression of angiogenesis.3)We found that dominant negative HIF-1α decreased the resistance to apoptosis induced by hypoglycemia.4) We also found that dominant negative HIF-1α decreased the tumorigenicity of a pancreatic cancer cell line.5)We demonstrated that dominant negative HIF-1α decreased the expression of Glut-1 enhanced by hypoxia and that dominant negative HIF-1α decreased the uptake of FDG in tumor tissues.