Establishment of optimal anti-angiogenic therapy against cancer of oral cavity

口腔癌最佳抗血管生成疗法的建立

• 批准号: 21592397
• 负责人: KOBAYASHI Masanobu
• 金额: $ 2.91万
• 依托单位: Health Sciences University of Hokkaido
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592397/
• 关键词: 低酸素; 血管新生; 血管新生阻害剤; 腫瘍増殖; 遺伝子発現; アドレノメジュリン; アドレノメジュリン阻害; セリンスレオニンカイネース; pim-1; アポトーシス; 口腔癌; HIF-1; adrenomedullin

By the method of DNA microarray system, which can detect the genes expressed under under hypoxia, we identified the genes of adrenomedullin and pim-1.Tumor growth of cancer cells of oral cavity in a mouse model system and the angiogenesis stimulated by adrenomedullin was inhibited by adrenomedullin-antagonist.

利用基因芯片技术检测了肾上腺髓质素（adrenomedullin，adrenomedullin）和pim-1基因在低氧条件下的表达情况。在小鼠口腔癌肿瘤模型中，adrenomedullin诱导的肿瘤血管生成被adrenomedullin拮抗剂抑制。

项目成果

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

• DOI: 10.2353/ajpath.2009.080900
• 发表时间: 2009-11-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Onuma, Kunishige;Sato, Yu;Okada, Futoshi
• 通讯作者: Okada, Futoshi

p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5

• DOI: 10.1002/ijc.25345
• 发表时间: 2011-01-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Kobayashi, Takahiko;Ishida, Junich;Brachmann, Rainer K.
• 通讯作者: Brachmann, Rainer K.

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

• DOI: 10.1038/onc.2009.124
• 发表时间: 2009-07-16
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Chen, J.;Kobayashi, M.;Darmanin, S.;Qiao, Y.;Gully, C.;Zhao, R.;Yeung, S. C.;Lee, M. H.
• 通讯作者: Lee, M. H.

Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization.

• DOI: 10.3892/ijo_00000622
• 发表时间: 2010-06
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: K. Tsuchiya;K. Hida;Y. Hida;C. Muraki;N. Ohga;T. Akino;T. Kondo;T. Miseki;K. Nakagawa;M. Shindoh;T. Harabayashi;N. Shinohara;K. Nonomura;Masanobu Kobayashi

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

• DOI: 10.2353/ajpath.2009.080972
• 发表时间: 2009-07-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Chen, Jian;Kobayashi, Masanobu;Lee, Mong-Hong
• 通讯作者: Lee, Mong-Hong