ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION

将转基因猪（人DAF）和正常猪的心脏原位移植到恒河猴体内。与正常猪移植的猕猴均不能断奶，移植物表现出高级别超急性排斥反应（HAR）。移植转基因DAF猪心脏的猴子可以从CPB中断奶，移植物没有出现HAR，但所有动物在再灌注后7小时内死亡。这些数据表明DAF可以延长异种移植物的存活时间，但不足以使动物存活超过一天。

The hearts of transgenic pig (human DAF) and normal pig were transplanted orthotopically into rhesus monkey. No monkeys transplanted with normal pigs could weaned from cardiopulmonary bypass (CPB) and the grafts showed high grade hyperacute rejection (HAR). Mokeys transplanted with transgenic DAF pig hearts could be weaned from CPB and grafts did not show HAR, however all animals died within 7 hours after reperfusion. These data suggested DAF may extend xenograft survival, but not enough to make animal survive more that a day.