Development of a quantitative diagnostic method of ^<19>F drug metabolism using clinical MRI

由于1998年科研资助已经结束，我们成功地观测到了临床剂量的~ 1F-MRS人体信号<19>。在该初步实验中获得的μ F的信号在消化器官肿瘤手术后的进展<19>良好，并且处方下的5-FU的信号是在服用作为抗肿瘤剂的5-FU的情况下通过关于病例的常规医学治疗过程从肝脏区域获得的。虽然在这种情况下的药物量相对少至100 mg或更少，但由于获得了良好的信号，为了推进作为临床诊断方法的部署研究，从而进一步导致直接的医疗治疗计划，1999年建立了5-FU、抗精神病药物和麻醉药物的临床设备中的测量方法的建立，氟含量药物曲线测量限的校核及最佳测量方法的参数 ...更多信息 本<19>研究采用动态MRS测量方法，对活体内同化和异化代谢的药物动力学进行了研究，并从药物代谢角度对肝功能评价和药代动力学进行了评价研究。这些研究成果可供参考。2000年对临床研究设备进行了更新，尝试了与独立型多核素测量谱仪的混合组合，并正在建设可在临床设备内自由进行多核素测量的系统。此外，还进行了开发和调整，以便可以从用于临床的设备进行直接氟化物等的测量。2001年，多核素光谱和使用光谱成像方法的研究结果被公布为提高氟化物测量灵敏度的环隙线圈的试制检查。一个寄存代理的本地化也成功地在一个图片（^<19>F-CSI），目前的结果是在贡献。评估储存剂的空间分布和代谢是未来部署研究的重要目标之一。少

As a result of the grant-in-aid for scientific research already ended by 1998, we succeeded in observing the signal from the human body of ^<19>F-MRS by the amount of clinical dose. The progress after a digestive organ neoplasm operation of the signal of ^<19>F obtained in this preliminary experiment is good, and the signal of 5-FU under recipe is acquired from a liver domain through the usual medical treatment course about a case while taking 5-FU which is an anti-neoplasm agent. Although the amount of medication in this case is comparatively as little as 100mg or less, since the good signal was acquired, in order to advance deployment research as a clinical diagnostic method which leads to a direct medical treatment plan further, 1999 set up establishment of the measuring method in the equipment for clinical of 5-FU, anti-psychosis medicine, and an anesthetic drug, the check of a measurement limit, and the parameter of the optimal measuring method as a fluoride content medicine curre … More ntly used as present medical supplies about evaluation of ^<19>F-MRS. Pharmaceutical kinetics of assimilation and dissimilation metabolism in the living body was performed with the dynamic MRS measuring method, and evaluation research on the liver function evaluation and the pharmacokinetics, which were seen from medicine metabolism, was also done. These researches were exhibited as reference. The research equipment for clinical is updated in 2000, hybrid composition with the independent type spectro-meter for multi-nuclide measurement is tried, and the system which can perform multi-nuclide measurement freely within the equipment for clinical is under construction. Moreover, development and adjustment are performed so that measurement of direct fluoride etc. can be performed from the equipment for clinical. In 2001, the multi-nuclide spectrum and the research result using spectroscopic imaging methods were announced as the trial production examination of the loop gap coil for a raise in the sensitivity of fluoride measurement. Localization of a depository agent is succeeded also in a picture (^<19>F-CSI), and the present result is under contribution. It is one of the important targets of the future deployment research to evaluate of a spatial distribution and metabolism of a depository agent. Less