Oncogenic viruses and malignant tumors in tropical Africa

我们对东非肯尼亚西部的恶性肿瘤进行了流行病学、组织学和病毒学研究。初步结果如下：1)以躯干播散性皮肤丘疹为主要表现的艾滋病相关性卡波西肉瘤的数量正在增加；2)在恶性肿瘤中，疑似与人乳头瘤病毒(HPV)有关的宫颈癌的发病率在增加，在艾滋病高发区，患者的平均年龄呈年轻化趋势；3)组织学上，血管瘤样卡波西肉瘤的数量增多；4)超微结构上，我们发现了三种类型的卡波西肉瘤细胞，它们分别分化为内皮细胞、周细胞和平滑肌细胞。5)人疱疹病毒(HHV)-8在几个Kaposi肉瘤和肿瘤周围的B淋巴细胞中呈阳性；6)大部分宫颈癌原位杂交显示HPV阳性；7)大部分儿童霍奇金病患者免疫组织化学和原位杂交显示EB病毒阳性。

We performed an epidemiological, histological and virological study of malignant tumors in the western part of Kenya, East Africa. Preliminary results are as follows ; 1)AIDS-related Kaposi's sarcoma, which shows disseminated cutaneous papules on the trunk, is increasing in number, 2)The incidence of cervical cancer, which suspected to be related with human papilloma virus(HPV), is increasing among the malignant tumors and a mean age of the patients is becoming younger in AIDS prevalent areas, 3)Hemangioma-like Kaposi's sarcoma is increasing in number histologically, 4)Ultrastructurally we found three types of Kaposi's sarcoma cells, which are differentiating to endothelial cell, pericytes and smooth muscle cells respectively, 5)Human herpes virus(HHV)-8 are found positive among several kaposi's sarcomas and also B lymphocytes around tumors, 6)Almost of cervcal cancers show HPV positive by in situ hybridization, 7)Majority cases of pediatric Hodgkin's disease shows Epstein-Barr virus positive by immunohistochemical methods and in situ hybridization.