Signal transduction of dietary fat and energy metabolismsthrough nucrea receptor

肥胖成为许多众所周知的生活的基础，即主要因素，习惯性疾病的出现，与疾病的出现有很深的关系。就本研究而言，那种肥胖形成的基础并不是我们对脂代谢和能量交换机制的关注。该机制在脂肪组织的增殖中起着决定性的作用，分析了针织机结构显露的控制与白色和棕色脂肪细胞分化形成的关系。至于执行死刑。人们到目前为止，长链脂肪酸成为肥胖增生症即白色脂肪组织的配基，PPAR作为转录水平上调控基因表达的主调控因子，在世界范围内迅速发现了PPAR作为脂肪酸感受器、脂代谢和能量代谢…的功能进一步受到修饰的事实更多的ISM相关基因揭示以某种信号转导机制是否控制上述信号转导机制，对于能量交换系统的功能发挥是否可能受到膳食因素的修饰而降低的脂代谢进行研究。我们分析了明确的3点作为研究目的。结果表明，PPAR控制着脂肪代谢和能量交换型基因的转录，是源于脂肪酸的一种配体，而且在信号转导系统中该核转录因子的细胞共激活因子，特别是CREB连接蛋白(CBP)与PPAR配体过饱和的情况下，CBP的显示量所规定的代谢细节电子的显示量在体内变得更加清晰，如同系物p300深入参与的高脂食物摄入中。此外，它还存在于棕色脂肪组织中，并偏离了与机体热产生密切相关的辅助激活蛋白(UCP)，以揭示由此而导致的脂代谢下降。它是由PPAR控制的，具有高度不饱和脂肪酸和植物来源的异戊二烯等PPAR配体，提示了能量交换系统功能再现的可能性。较少

Obesity became the basis, namely principal factor of many generally known life, habit illness emergences, being related with sick condition emergence deeply was ascertained. As for this research, foundation of that kind of obesity formation it is not we pay attention to lipid metabolism and the energy exchangemechanism. The mechanism decisively carry out important role in hyperplasia of adipose tissue, relation between the control of revelation of knitting machine structure and differentiation formation of white and the brown fat cell was analyzed. As for the execution. people, so far, the long-chain fatty acid became the ligand in hyperplasia of obesity namely white adipose tissue and PPAR controlled gene revelation at transcriptional level as a master regulator, beginning discovered the fact that the function receives decoration furthermore with the various nutrients promptly in the world.At the time of this researching PPAR as a fatty acid sensor, lipid metabolism and energy metabol … More ism relating gene revelation are controlled with some kind of signal transduction mechanism whether the above-mentioned signal transduction mechanism, it receives the decoration with meal factor whether the lipid metabolism which decreases as for functional playback of energy exchange system possibility research. We analyzed clear 3 points as study purposes.As a result, PPAR controlling transcription of the.,lipid' metabolism and the energy exchange type gene having a meal the fatty acid of origin a ligand, furthermore in signal transduction system inside 'this cell coactivator factor of nuclear transcriptional factor, the especially CREB connection protein (CBP) with the PPAR ligand over saturation under condition, the revelation quantity Of the metabolism details electron being stipulated by the revelation quantity of CBP became clearr in vivo such as thing and the high fat food intake where that homolog p300 has participated deeply. In addition, it existed in brown adipose tissue and the deviation from coactivator protein which relates to body thermal production deeply (UCP) as for revelation the lipid metabolism which decreases from thefact that. it is controlled by PPAR, with PPAR ligand such as highly' unsaturated fatty acid and plant origin isoprenoid, possibility of functional playback of energy exchange system was suggested. Less