Development of intraoperative brain function endoscope with intrinsic optical imaging and fiber optics

我们在9例脑肿瘤/癫痫手术中应用本征光学成像技术对人类初级体感觉皮层进行了观察。在操作显微镜下用氙灯照射皮质表面，通过605nm带通滤光片的反射光通过CCD相机光学成像系统进行检测。对五个手指进行单独的电刺激会引起反射光强度的变化。可视化固有的光学响应，我们在Brodmann的区域1构建了手指表示的地图。在图中，从后下位区（后下位区）到中上位区（后上位区），依次沿着中央后回冠的中央沟排列。邻近的反应区域部分重叠，正如之前在猴子体感皮层中描述的那样。在三叉神经的三个分支的刺激下，在面部区域获得了类似的结果。这些结果表明，反应区域的重叠是体感觉皮层的一个共同特征，不仅在猴子中，而且在人类中。

We applied the intrinsic optical imaging technique to the human primary somatosensory cortex during brain tumor/epilepsy surgery for nine patients. The cortical surface was illuminated with a Xenon light through an operating microscope, and the reflected light, which passed through a 605nm bandpass filter, was detected by a CCD camera-based optical imaging system. Individual electrical stimulation of five digits induced changes in the reflected light intensities. Visualizing the intrinsic optical responses, we constructed maps of finger representation in Brodmann's area 1. In the maps, response areas of Digit I to V were sequentially aligned along the central sulcus in the crown of the postcentral gyrus from the latero-inferior region (Digit I) to the medio-superior region (Digit V). The neighboring response areas partially overlapped each other, as previously described in the monkey somatosensory cortex. Similar results were obtained in the face region with stimulation of the three branches of the trigeminal nerve. These results suggest that the overlap of the response areas is a common feature in the somatosensory cortex not only in monkeys, but also in humans.