INTRINSIC SIGNAL IMAGING IN THE BRAIN

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在这项研究中，我们建议使用光谱和偏振技术，推动光学固有信号成像（ISI）的限制，对测量快速响应的照明皮层刺激输入。 在本研究中，快速信号定义为发生时间短于血流动力学反应的信号，血流动力学反应发生在秒级。 因此，我们建议对皮质中的光反射率变化进行成像，这些变化是由于激活的神经元中的电信号（约10毫秒）和脱氧血红蛋白的瞬时增加（称为初始下降）（约100毫秒）。 这种快速信号对于理解至关重要，因为它们是大脑对刺激反应中最不了解的部分，并且是神经活动的直接测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this study, we propose to use spectroscopic and polarimetric techniques to push the limits of optical intrinsic signal imaging (ISI) towards measuring the fast response of an illuminated cortex to a stimulus input. For this study, fast signals are defined as those that take place on timescales shorter than the hemodynamic response, which occurs on the order of seconds. Thus we propose to image light reflectance changes in the cortex that are due to electrical signals in the activated neurons (~10s of milliseconds) and to the transient increase in deoxygenated hemoglobin known as the initial dip (~100s of milliseconds). Such fast signals are crucial to understand because they are the least understood part of the brain response to a stimulus and are a direct measure of neural activity.