INTRINSIC SIGNAL IMAGING IN THE BRAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这项研究中，我们建议使用光谱和偏振技术来推动光学本征信号成像(ISI)的极限，以测量大脑皮质对刺激输入的快速反应。在这项研究中，快速信号被定义为那些发生在比血流动力学反应更短的时间尺度上的信号，后者发生在几秒钟的量级上。因此，我们建议成像皮质中的光反射变化，这些变化是由于激活的神经元中的电信号(~10s毫秒)和被称为初始DIP的脱氧血红蛋白的瞬时增加(~100s毫秒)。如此快速的信号对于理解是至关重要的，因为它们是大脑对刺激反应中最不被理解的部分，是神经活动的直接衡量标准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we propose to use spectroscopic and polarimetric techniques to push the limits of optical intrinsic signal imaging (ISI) towards measuring the fast response of an illuminated cortex to a stimulus input. For this study, fast signals are defined as those that take place on timescales shorter than the hemodynamic response, which occurs on the order of seconds. Thus we propose to image light reflectance changes in the cortex that are due to electrical signals in the activated neurons (~10s of milliseconds) and to the transient increase in deoxygenated hemoglobin known as the initial dip (~100s of milliseconds). Such fast signals are crucial to understand because they are the least understood part of the brain response to a stimulus and are a direct measure of neural activity.