DEVELOPMENT OF PERITONEAL DIALYSIS SYSTEM WITH A WEARABLE ARTIFICIAL KIDNEY UNDER NO DIOALYSATE REPLACEMENT

在这项研究中，我们介绍了一种改良的CRPD/BPD系统，该系统采用新开发的可穿戴人工肾脏，利用白蛋白溶液作为渗透剂。在犬的体外实验中，研究了该系统的水和溶质去除特性。1)可穿戴式人工肾脏：根据使用特定三醋酸纤维素膜的测试透析仪的性能进行初步研究，在分析研究中确定最佳透析仪的规格。该透析器将用于CRPD/BPD系统中废腹膜透析液的再生。一款可穿戴式透析器是由Nipro公司的Hiroyuki Hattori从经济角度出发开发的。2)犬体外实验：采用双侧肾切除犬进行腹膜透析实验，考察该系统对水和溶质的去除特性。在实验开始前，将含有几种标记溶质的溶液注入狗体内。通过模拟方法获得了标记物溶质浓度的时间核心，并确定了传质面积系数等参数。3)白蛋白添加透析液：为了检验含白蛋白透析液作为渗透剂的有效性，对犬进行了体外实验。在临床情况下，10%白蛋白和1.0%葡萄糖的组合是最有效的水去除。

In this study, we introduced a modified CRPD/BPD system with a newly developed wearable artificial kidney and utilizing albumin solution as an osmotic agent. Water and solute removal characteristics in this system were examined during an canine in vitro experiemts.1)Wearable artificial kidney : As a result of preliminary study beased on parformance of a test daialyzer with a specific cellulose triacetate membrane, specifications of the optimum dialyzer colud be determined during an analytical study. This dialyzer will be used for the regeneration of the spent peritoneal dialysate in the CRPD/BPD system. A wearable dialyzer was developed by a co-investigator in this research, Hiroyuki Hattori, belonging to Nipro Company Limited on an account of an economical viewpoint.2)Canine in vitro experiments : Peritoneal dialysis experiments using bilaterally nephrectomized dogs were carried out to examine the water and solute removal characteristics in this system. Before the start of the experiment, an solution involving several marker solutes was infused ti the dog. Time corce of solute concentration of the marker was obtained and sevreal parameters such as nass transfer-area coefficient was determined by a simulation method.3)Albumin additive dialysate : In order to exmine a validity of the dialysate containing albumin as an osmotic agent, canine in vitro experiemnts were carried out. A combination of 10 % albumin with 1.0 % glucose was most effective for water removal in a clinical situation.