Radiofrequency ablation with intratumoral injection of magnetic substance

为了研究肿瘤内注入磁性物质对凝固范围的影响，进行了基础实验。将17G、非绝缘长度2cm的射频针插入蛋白中，通过改变一个输出进行高频通电实验。测定了凝固区域在固定时间内的直径，同时观察了蛋白的凝固情况。然后，将含有蛋白中磁性物质铁的磁性物质γ-Fe2O2/C6H11O6-(C6H10O5)n-C6H11O5混合，用类似的实验系统进行实验。在高频输出30W时得到的凝固范围最大，得到的凝固区域为1.8 ~ 2.3cm。在此基础上，利用磁性物质中最优的实验体系对蛋白包埋组和蛋白包埋组进行了通电。结果表明，在向蛋白中注入磁性物质864mg（铁：44.6 mg）的组中，凝固范围比仅注入蛋白的组更早扩大，且从通电起始时间点无法识别10 Ω以上的环和电阻值。此外，在注入磁性物质1728mg（铁：89.2 mg）的倍数后，蛋白的凝固范围在短时间内扩大，在9分钟内获得电阻值，并从通电开始上升到10 Ω以上。磁性物质经皮下注射后，在猪肺组织内看到磁性物质，基本实验相同的高频热凝治疗，在短时间内通过灼烧获得较宽的凝固性坏死。

Basic experiment under the sake which investigates the change of solidification range by the intratumoral magnetic substance injection was performed. The radiofrequency needle 17G and non-insulation length 2cm is inserted in the albumen, and it performed by the change of an output of the high frequency energization experiment. The diameter of solidification region in the fixed time was measured, while the solidification of the albumen is observed. Next, magnetic substance (molecular formula : γ-Fe2O2/C6H11O6-(C6H10O5)n-C6H11O5) which contained the iron which is a magnetic substance in the albumen was mixed, and the experiment was enforced by the similar experimental system. The largest solidification range is obtained the result at high frequency output 30W, and it obtained the solidification region 1.8-2.3cm.Referring to these results, the energization was enforced in the group which was entrapped in albumen group and albumen by the optimum experimental system in magnetic substance.As the result, in the group which injected magnetic substance 864mg (iron:44.6 mg) into the albumen, the solidification range expanded in comparison with the group only of the albumen early, and the rise over 10 Ω could not be recognized hoop and resistance value from energization start point of time. In addition, solidification range expanded in the albumen which injected magnetic substance 1728mg (iron:89.2 mg) of the multiple in the short time, and the resistance value was obtained in 9 minutes, and the rise over 10 Ω was obtained from the energization start.After magnetic substance was endermically injected, when it saw in the pulmonary tissue of the pig, basic experiment identical high frequency heat coagulation therapy, the wide coagulative necrosis was obtained by the cauterization in short time.