Development of new-designed device ("simultaneous transcranial measurement system of multiple electrical pulse impedances using multi-polar circuit method") to measure local cerebral blood flow

我们新设计并开发了一套测量多点局部脑血流量的系统（“多极电路法多电脉冲阻抗同步经颅测量系统”）。实际上，经颅可以测量局部脑血流的8个点。该系统围绕头部旋转，并在每个点测量电阻抗。我们加载了三种不同的任务组，如光刺激、二氧化碳加载和相似数据之间的差异。在相似图形差异指向测试中，双侧颞枕区检测到的阻抗发生了显著变化。在光刺激下，这种变化在枕区被检测到。在CO2加载过程中，发现了整个区域的阻抗变化。我们在动物模型上进行了这些测试，并检查了在志愿者身上得到的阻抗变化，在动物模型中也会发现，并测试了阻抗变化与颅内压变化之间的关系。然而，同样的系统在动物实验中建立起来也花了很长时间，而且我们在动物实验模型中也没有得到很好的结果。在不久的将来，我们将完成同样的动物实验系统的制作，并在实验动物身上试用该系统，并检查志愿者使用该系统的结果是否代表了局部脑血流的真实变化。

We newly designed and developed a system ("simultaneous transcranial measurement system of multiple electrical pulse impedances using multi-polar circuit method") to measure multi-point local cerebral blood flow. Actually, 8 points of local cerebral blood flow can be measured transcranially. The system rotates around the head and electrical impedance is measured at each point.We loaded three different kinds of task forces, such as light stimulation, loading of CO2, and pointing of difference between similar figures. In the test of pointing of difference between similar figures, impedance detected from bilateral temporo-occipital areas were significantly changed. In the light stimulation, such change was detected in occipital areas. In the loading of CO2, impedance change in the whole area was found.We tried these tests using animal model, and examined the impedance change, which was obtained in volunteers, would also found in the animal model, and also tested the relation between the impedance change and change of intracranial pressure. However, it took unexceptionally longer time to establish the same system for animal experiment, and we did not get good results in the animal experimental model yet.In near future, we will finish to produce the same system for animal experiment, and try this system to the experimental animal, and examine weather the results using this system for volunteers represent real change of local cerebral blood flow or not.