The Biological Role of SCC Antigen in Head and Neck Cancer

丝氨酸蛋白酶在肿瘤的侵袭和转移过程中起重要作用，其抑制剂丝氨酸蛋白酶抑制剂（sereproteinhibitors，serpins）是一种极具吸引力的治疗靶点。在染色体18 q21上，有一簇丝氨酸蛋白酶抑制剂; maspin，headpin和SCCA 1。其他人和我们已经报道，与正常鳞状上皮细胞相比，这些丝氨酸蛋白酶抑制剂的表达在HNSCC细胞中下调。我们假设SCCA 1的表达对HNSCC细胞在生物学上是不利的。与载体对照相比，用具有SCCA 1 cDNA的哺乳动物表达载体稳定转染的已建立的HNSCC细胞系的体外和体内侵袭被显著抑制。SCCA 1可能具有抑制HNSCC侵袭的作用。我们还报道了血清SCC抗原水平与鼻窦内翻性乳头状瘤（IP）的疾病状态相关，并有可能作为监测疾病过程的有用工具。SCC抗原是治疗鼻腔鼻窦IP的可靠肿瘤标志物。

Serine proteases have important roles in tumor invasion and metastasis and their inhibitors, serine protease inhibitors (serpins) are attractive targets for therapeutic strategies. On chromosome 18q21,there is a cluster of serpins ; maspin, headpin, and SCCA1. Others and we have reported that the expression of these serpins are down-regulated in HNSCC cells as compared to normal squamous epithelial cells. We have hypothesized that expression of SCCA1 is biologically disadvantageous to HNSCC cells. The in vitro and in vivo invasion of established HNSCC cell lines stably transfected with a mammalian expression vector with SCCA1 cDNA was significantly inhibited compared to the vector control. SCCA1 may function to inhibit the invasive potential of HNSCC.We also reported that Serum SCC antigen level has a correlation with disease status of sinonasal inverted papilloma(IP) and has a potential to serve as a useful tool for monitoring the course of disease. SCC antigen is a reliable tumor marker in the management ofsinonasal IPs.