Study on Development of Antibacterial Dental Resin using Silver Methacrylate as an Antibacterial Substance

迄今为止，已有将银离子作为抗菌物质的牙科树脂的研究。将银离子固定在沸石等载体上，将载体与树脂混合，制成复合树脂。由于银离子在复合材料中的分散不均匀，使复合树脂的韧性下降，因此尝试以甲基丙烯酸银单体（MAG）为抗菌物质，研制抗菌牙科树脂。考察了甲基丙烯酸甲酯（MMA）中甲基丙烯酸缩水甘油酯（MAg）的溶解度，并对含MAg的MMA进行了聚合，测试了聚合物的力学性能。结果，MAg以84×10 μ <-6>mol/l（约9 ppm）的浓度溶解于MMA。由于银离子对大肠杆菌的最小消光浓度为3 × 13 ppm，因此认为该浓度足以使抗菌活性显现。MMA与2-甲基丙烯酰氧乙基三甲基氯化铵（MC）共聚物的抗压强度和弯曲强度随MC含量的增加而降低。然而，所获得的含MAG的树脂是透明无色的，并且在美学上没有问题。树脂的抗压强度和弯曲强度与PMMA相比无显著性差异。树脂中的银离子不溶于水。含镁树脂有望成为牙科抗菌树脂。

There is the research of dental resin which made silver ion to be antibacterial substance until now. The silver ion is fixed to the carrier such as zeolite, the carrier is mixed with the resin, and the composite resin is made. The silver ion has not uniformly been dispersed in composite material, and in addition the toughness of the composite resin decrease.The development of antibacterial dental resin using silver meyhacrylate monomer (MAg) as an antibacterial substance was tried. The solubility of MAg in methyl methacrylate (MMA) was examined, and then the mechanical property of the polymer obtained by polymerization of MAg-containing MMA was tested. As a results, MAg was dissolved to MMA in a concentration of 84×10^<-6> mol/l (about 9 ppm). And it was suggested that the concentration was enough for the appearance of antibacterial activity, because the smallest extinction concentration of silver ion for a Escherichia coil is 3〜13ppm. The Compressive and bending strength of the copolymer of MMA and 2-Methacryloyloxyethyltrimethyl ammonium chloride (MC) decreased with the content of MC. However MAg-containing resin obtained was transparent colorlessness, and there was no problem in esthetics. The compressive and bending strength of the resin were not significantly different compared with those of PMMA The silver ions in the resin does not dissolve into water. MAg-containing resin can be expected as an antibacterial dental resin.