The changes of renal function after the simultaneous injection of different type of contrast media: experimental study on healthy and diabetes mellitus nephropathy rats

目的：观察链脲佐菌素肾病大鼠和健康大鼠同时注射不同类型造影剂Gd-DTPA和IopamIron后肾功能的变化。材料和方法：实验分为正常大鼠和链脲佐菌素糖尿病肾病大鼠。试验溶液为造影剂混合液(Magnevist+IopamIron)、生理盐水组和甘露醇组。尿量增加，组间差异无统计学意义。血清肌酐值呈一过性升高，随时间延长呈下降趋势。血、尿氮无明显升高。未观察到内生肌酐清除率显著下降。钠排泄分数一过性增加，但组间无显著差异。结论：正常和链脲佐菌素诱导的糖尿病肾病大鼠同时注射不同类型造影剂后，肾功能的变化不是很严重和短暂。

Objective : to investigate the changes of renal function after the simultaneous injection of different type of contrast media including Magnevist (Gd-DTPA) and Iopamiron (Iopamidol) on healthy and streptozotocin induced diabetes mellitus nephropathy rats.Materials and methods : Experimental groups consist of healthy rats and streptozotocin induced diabetes mellitus nephropathy rats. Test solutions are contrast media mixture group (Magnevist+Iopamiron), physiological saline group, and manitol group.Results : Hematocrit value was not increased. Urine volume was increased without any significant difference among groups. Serum creatinine value was transiently increased, and declined with time. There was no significant increase in blood urine nitrogen value. No significant decrease in Creatinine clearance was observed. Fraction excretion of sodium was transiently increased, while no significant difference was observed among groups. Free water clearance was transiently decreased, while no significant difference was observed among groups.Conclusion : The changes of renal function after the simultaneous injection of different type of contrast media was not serious and transient on healthy and streptozotocin induced diabetes mellitus nephropathy rats