Development of Diagnostic Method for clinical utility on Thyroid Carcinoma by Chemical assay

胸腺球蛋白（Tg）由甲状腺产生，分子量为660，000道尔顿，碳水化合物含量约为10%。传统上，通过测定血清Thymoglobulin来随访分化型甲状腺癌。然而，免疫测定法测定的胸腺球蛋白浓度受血清中抗Tg自身抗体的影响很大，我们建立了LCA凝集素化学测定法（LCA反应性Tg法）用于甲状腺癌的临床诊断。对103例健康志愿者、159例甲状腺良性肿瘤、170例甲状腺癌患者血清进行LCA反应性Tg测定，发现甲状腺癌患者血清Tg值明显低于甲状腺良性肿瘤患者。血清LCA反应性Tg值对甲状腺癌与甲状腺良性肿瘤的鉴别诊断有一定的参考价值。

Thymoglobulin (Tg) is produced by the thyroid with a molecular mass of 660,000 Dalton and a carbohydrate content of approximately 10%. Traditionally, the follow-up of differentiated thyroid carcinoma by measured serum Thymoglobulin. However, the concentration of thymoglobulin measured by immunoassay is greatly affected by presence of anti-Tg autoantiboies in sera.We developed of new diagnostic method for clinical utility on thyroid carcinoma by chemical assay using LCA lectin(LCA reactive Tg method). The study was conducted on 103 serum samples form healthily volunteers, 159 patients with benign thyroid tumor, 170 patients with thyroid carcinoma.The values of LCA reactive Tg method in patients with thyroid carcinoma was significantly lower than in patients those with benign thyroid tumor with serum Tg. The values of LCA reactive Tg method in serum may be useful for distinguishing between thyroid carcinoma and benign thyroid tumor.