Association of retinal antigen Brn 3b with pathogenesis of Behcet's disease
Association of retinal antigen Brn 3b with pathogenesis of Behcet's disease
批准号:
14570241
负责人:
ISOGAI Hiroshi
金额:
$2.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
从人胚脑cDNA文库中扩增出约1kb的BRN 3b DNA片段。将该产物插入到大肠杆菌中,细菌产生BRN3b蛋白。用抗BRN3b合成肽的抗血清凝集细菌。此外,BD患者的几份血清也凝集了该毒株。结果提示BRN 3b蛋白与白塞病的发病相关,目前已是发育成转基因小鼠的最后阶段。
英文摘要
About 1kb of Brn 3b DNA was obtained PCR from cDNA library of human embryonic brain. The product was inserted into Escherichia coli and the bacteria produced Brn 3b protein. The bacteria strain was agglutinated by anti-serum to synthetic peptide of Brn 3b. Furthermore, several sera from the patients with BD agglutinated this strain. The results suggested that the Brn 3b protein was correlated with the Behcet's disease.Now, it is the final stage for developing TG mice which were inserted this DNA.
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Antimicrobial activity of synthetic human CAP 18 peptides to Streptococcus sanguis isolated from pateints with Behcet's disease. In : Adam antiades -Behcet's disease (Ed : C.C.Zouboulis)
合成人 CAP 18 肽对从白塞氏病患者分离出的血链球菌的抗菌活性。
DOI:
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发表时间:
2003
期刊:
Advances in Experimental Medicine and Biology(Kluwer Academic/Pleunum Publishers, New York) Vol 528
影响因子:
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作者:
[Isogai E, Hirata M, Isogai H., Matuso K., Kimura K, Yokota K, Oguma K, Tojo M, Kaneko F, Kotake S, Ohno S]
通讯作者:
Ohno S
Emiko Isogai: "Antibody cross reactivity from sera of patients with Behcet's disase with synthetic peptides that have homologies with proteins from Streptococcus sanguis"The Journal of Applied Research. 2(3). 185-191 (2002)
Emiko Isogai:“白塞病患者血清中的抗体与与血链球菌蛋白质具有同源性的合成肽发生交叉反应”应用研究杂志。
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通讯作者:
E.Isogai: "Antibody Cross Reactivity From Sera of Patients With Behcet's Disease With Synthetic Peptides That Have Homologies With Proteins From Streptococcus sanguis"Journal of Applied Research. 2・3. 1-7 (2002)
E.Isogai:“白塞氏病患者血清与与血链球菌蛋白质具有同源性的合成肽的抗体交叉反应”应用研究杂志 1-7 (2002)。
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Antibody cross reactivity from sera of patients with Behcet's disease with synthetic peptides that have homologies with protein from Streptococcus sanguis.
白塞氏病患者血清中的抗体与与血链球菌蛋白具有同源性的合成肽发生交叉反应。
DOI:
--
发表时间:
2002
期刊:
J.Appl.Res. 2(3)
影响因子:
--
作者:
[Isogai E, Isogai H, Kotake S, Ohno S, I shihara M, Aoki K, Tojc M, Kaneko F, Yokota K, Oguma K]
通讯作者:
Oguma K
Emiko Isogai: "Antimicrobial activity of synthetic human CAP18 peptides to Streptococcus sanguis isolated from patients with Behcet's disease"Advances in experimental medicine and Biology. 528. 195-200 (2003)
Emiko Isogai:“合成人 CAP18 肽对从白塞氏病患者中分离出的血链球菌的抗菌活性”实验医学和生物学的进展。
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共 9 条
The approach of synthetic steroid ceragenin to curative medicine for infectious diseases
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批准号:22590397
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2010
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负责人:ISOGAI Hiroshi
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依托单位:
Study of Helicobacter pylori infection using G-CSF transgenic mice.
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批准号:10670264
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1998
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负责人:ISOGAI Hiroshi
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依托单位:
Experimental Study of Metastasis and Invasion Related Oncogene by Using Oral Cancer Cell Lines
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批准号:09672032
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1997
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负责人:ISOGAI Hiroshi
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依托单位:
海外基金