Comparison of sensitivities for colorectal cancer between the guaian-based fecal occult blood test (FOBT) and an immunochemical FOBT.

本研究旨在比较免疫化学粪便潜血试验（IFOBT）与愈创木脂FOBT的敏感性。受试者是2858人谁接受结肠镜检查的一部分，多相健康检查和523例门诊患者没有血便谁接受结肠镜检查，因为腹部症状的胃肠单位。IFOBT和FOBT分别在151和338例受试者中获得阳性结果。在16例结直肠癌患者中，IFOBT阳性10例，愈创木脂FOBT阳性5例。IFOBT和FOBT的灵敏度分别为63%和31%。两种检测之间的灵敏度无统计学显著差异（p=0.08），可能是由于样本量较小和首次筛选者比例（约10%）低于本研究开始时的预期。IFOBT的敏感性高于FOBT，但需要更大的样本量才能获得显示其重要性的结果。

This study was conducted to compare sensitivity of immunochemical fecal occult blood test(IFOBT) with that of guaiac FOBT. Subjects were 2858 individuals who underwent colonoscopy as part of a multiphasic health examination and 523 outpatients without bloody stool who underwent colonoscopy at a gastrointestinal unit because of abdominal symptoms. Positive results were obtained in 151 and 338 subjects with IFOBT and FOBT, respectively. Cancer was found in 10 individuals and 6 outpatients.IFOBT gave positive results in 10 out of 16 patients with colorectal cancer, while guaiac FOBT did 5 out of 16. Sensitivities were calculated to be 63% and 31% for IFOBT and FOBT, respectively. There was no statistically significant difference in sensitivity between the two tests (p=0.08) probably due to a smaller sample size and a lower proportion of first-time screenees (approximately 10%) than those expected at the beginning of this study. IFOBT was suggested to be higher in sensitivities than FOBT, however, a larger sample size will be needed to obtain significant results showing it.