Cognitive behavior therapy using with atypical anti-psychotics to improve insight of schizophrenia

我们测试了认知行为程序与非典型抗精神病药物联合使用是否提高了对精神分裂症的洞察力。1)试点研究东京大学医院诊断为精神分裂症(JCD10)的日间治疗中心的9名成员参加了由22个一小时的疗程组成的认知行为程序。与治疗前比较，社交技能、阴性症状、情感症状、无组织症状、GAS、连线测验、词语流利性测验、自知力均有明显改善。2)社会技能、自知力与认知功能的相关性研究对36例精神分裂症(ICDlO)患者的精神症状、自知力、认知功能和社交技能进行了评定。自知力(治疗依从性)的一个组成部分与社交技能有关。自知力(对精神障碍的认知)的另一个成分与情感症状和思维流畅性有关。3)疗效研究概要集中在洞察力上。非典型性抗精神病药物-认知行为程序组、常规抗精神病药物-认知行为程序组和非典型抗精神病药物-常规门诊治疗组均在东京经济大学医院完成。每组8人。认知行为训练计划20个疗程，将持续到2004年3月。将分析该计划和非典型抗精神病药物对精神分裂症自知力的影响。

We tested whether cognitive-behavioral program using with atypical antipsychotics improved insight of schizophrenia.1) Pilot studyNine members of the day treatment center of Teikyo University Hospital diagnosed with schizophrenia (JCDlO) attended the cognitive behavior program which consisted of 22 one-hour sessions. As compared with pre and post treatment, social skills, negative symptoms, affective symptoms, disorganized symptoms, GAS, the trail making test, the word fluency test, insight were significantly improved. Modification of coping skills, affective symptoms, and disorganized symptoms of 5 members with atypical antipsychotics improved significantly more than 4 members with conventional antipsychotics.2) Correlational study among social skills, insight, and cognitive functioning Thirty six diagnosed with schizophrenia (ICDlO) were assessed with psychiatric symptoms, insight, cognitive functioning, and social skills. One component of :insight (treatment compliance) was associated with social skills. Another component of insight (recognition of mental disorder) was associated with affective symptoms and thought fluency.3) Outline of efficacy study focused on insightAtypial antipsychotics-cognitive behavior program group, conventional antipsychotics-cognitive behavior program group, and atypial antipsychotics-usual outpatient treatment group were recruited at Teikyo University Hospital. The number of each group was 8. The cognitive behavioral program was planned 20 sessions, and will be finished until March 2004. The effects of the program and atypical antipsychotics on insight of schizophrenia will be analyzed.