SAFETY AND QUALITY OF RECOVERY FROM PROPOFOL ANESTHESIA-THE EFFECTS OF AMINOPHYLLINE-

1.异丙酚/芬太尼麻醉后恢复：氨茶碱（5mg/kg）可使患者对指令的正确反应更早恢复，定向能力更早恢复。在异丙酚麻醉后15和30分钟，患者在认知功能测试中的表现也有所提高。异丙酚/氧化亚氮麻醉后恢复：在血浆异丙酚浓度较高时，氨茶碱（5mg/kg）可使患者较早苏醒，较早恢复对指令的正确反应，较早恢复定向。在异丙酚麻醉后15和30 min，患者的认知和精神运动功能测试也有较高的表现。异丙酚镇静后恢复：接受氨茶碱治疗的患者精神运动功能（触发点测试）、运动平衡功能（重心波动）显著改善。异丙酚停药后5min，氨茶碱组潮末CO_2值明显降低。血清茶碱浓度升高未见不良反应。氨茶碱，一种腺苷受体拮抗剂，逆转了异丙酚的大部分作用。氨茶碱的逆转作用可能是通过对腺苷受体的拮抗作用介导的，腺苷受体特异性参与异丙酚的麻醉和镇静作用。本研究结果表明，氨茶碱有助于促进异丙酚麻醉后的恢复，并在麻醉后早期使用时提高警觉性。

1.Recovery from propofol/fentanyl anesthesia : Aminophylline (5mg/kg) resulted in earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive function tests at 15 and 30 min after propofol anesthesia.2.Recovery from propofol/nitrous oxide anesthesia : Aminophylline(5mg/kg) resulted in earlier awakening at higher plasma propofol concentration, earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive and psychomotor function tests at 15 and 30 min after propofol anesthesia.3.Recovery from propofol sedation : Psychomotor function (Triger Dot Test), motor equilibrium function (fluctuation of the center of gravity) improved significantly in those receiving aminophylline. At 5 min after discontinuation of propofol, the value of end-tidal CO_2 was significantly lower in those receiving aminophylline.No adverse side effect of increased serum theophylline concentration was observed.Aminophylline, an adenosine receptor antagonist, reversed most of the effects of propofol. Reversal effects by aminophylline may be mediated by antagonistic actions at adenosine receptors specifically involved in the anesthetic and sedative action of propofol. The results of the present study indicate that aminophylline is useful in facilitating recovery from propofol anesthesia and in increasing vigilance in the early postoperative period when used at emergence from anesthesia.