Development of the supporting system for the patients with multiple risk factors by exercise therapy

1)餐后糖脂代谢和运动疗法高敏C反应蛋白可能是高危肥胖女性的预测标记物，因为它与空腹和餐后游离脂肪酸以及餐后胰岛素水平独立相关。中等强度运动疗法可改善肥胖者的餐后血象，即使在正常脂肪餐后也是如此。2)最佳运动强度的确定乳酸门槛(LT)下的工作率与危险肥胖人群的数量显著相关。未发生ST段压低的是安全强度。胰岛素抵抗可能与运动中的病理性ST段压低有关，运动中的目标心率估计已从年龄确定，但我们建议应考虑其危险因素。此外，还需要根据体能和危险因素的改善对处方运动方案进行仔细的修改。无论有没有代谢综合征，都可以成功地检测到双乘积断点(DPBP)。DPBP的%BW是一项有用和可靠的指标，既可以用来在自行车测功机上选择合适的运动处方，也可以跟踪身体和代谢健康的时间趋势。膝关节骨关节炎和多种危险因素的患者的运动处方应该低于不存在骨关节炎的患者。3)身体素质对多个危险因素的损害和改善的机制和过程。单核细胞和中性粒细胞计数的变化与空腹和餐后甘油三酯和有氧能力的改善有关。在肥胖者危险因素的变化过程中，身体素质和代谢状况的改善先于体重的变化。

1) Postprandial glucose and lipid metabolism and exercise therapyHigh sensitive C-reactive protein may be a predictive marker in high risk obese women, because it is independently associated with both fasting and postprandial free fatty acid and postprandial insulin level. Mild intensity exercise therapy improves postprandial blood profiles even after normal fat meal in obese subjects.2) Determination of the optimal exercise intensityThe work rate at the Lactate threshold (LT) showed significant correlation with the number of risk fatocrs. LT is a safe intensity where ST segment depression has not occurred. Insulin resistance may involve the pathological ST depression during exercise.The estimated target heart rate during exercise has been determined from age, however we suggest that their risk factors should be taken into consideration. Futhermore, careful modification in the prescribed exercise regimen is needed according to improvement in the fitness and in risk factors.The breaking point in double product (DPBP) could be successfully detected in men and women with or without metabolic syndrome. The %BW at the DPBP was suggested to be a useful and reliable index for both an appropriate exercise prescription on a cycle ergometer as well as tracking the temporal trends in physical and metabolic fitness.The exercise prescription in the patients with both osteoarthritis of the knee and multiple risk factors should be lower than that for the patients without osteoarthritis.3) Mechanism and process of impairment and improvement in multiple risk factors by physical fitness.The change in the monocyte and neutrophil counts are associated with the inprovement in both fasting and postprandial triglyceride and aerobic capacity. In the process of the change in the risk factors in obese subjects, the improvement in the fitness and metabolic conditions precede to the changes in body weight.