Continuous measurement of biliary pressure with chronically implanted microtransducer catheter in anesthetized and conscious dogs

(简介)微型传感器测压是一种替代方法，可以在不需要输液的情况下延长胆道压力的记录时间。本研究的目的是观察麻醉清醒犬胆总管内长期置入微探头导管对胆道压力的影响。麻醉犬经Vater‘s乳头用微型换能器导管记录胆道压力。观察胆囊切除术前后应用CCK的效果。清醒犬在术后1周禁食和喂食状态下，经肝脏用微型换能器导管记录胆道压力。(结果)麻醉犬基础胆道平均压力为5.8 mm Hlg。胆囊收缩后注射CCK后，胆道压力(5 Mm Hg)略有升高。胆囊切除术后，注射CCK后胆管基础压立即下降。清醒犬进食后，胆汁压力随胆囊壁收缩而逐渐降低。注射CCK后，胆道压力略有升高，从基线开始逐渐下降。这种压力变化与胆囊壁相协调。(结论)新研制的微探头导管提供了有关胆道的额外信息。结果表明，胆总管压力与胆囊收缩有密切关系，餐后可观察到胆总管压力的变化。

(Introduction) Microtransducer manometry is an alternative that permits prolonged recording of biliary pressure without the need for infusion. The aim of this study was to investigate the detailed changes in biliary pressure with chronically implanted microtransducer catheter placed in the common bile duct in anesthetized and conscious dogs.(Material and Methods) The diameter of microtransducer catheter was 1.5mm. In anesthetized dogs, biliary pressure was recorded by microtransducer catheter through Vater's papilla. Effect of cholecystokin (CCK) was evaluated before and after cholecystectomy. In conscious dogs, biliary pressure was recorded by microtransducer catheter through the liver during fasted and fed state 1 week after operation. Gastrointestinal motility was simultaneously recorded by strain-gauge force transducers.(Results) In anesthetized dogs, biliary mean pressure at baseline was 5.8 mmHlg. Biliary pressure (5 mmHg) slightly increased after injection CCK following contraction of gallbladder. After cholecystectomy, biliary basal pressure decreased immediately after injection of CCK. In conscious dogs, biliary pressure gradually decreased following gallbladder contraction after feeding. After injection of CCK, biliary pressure slightly increased and gradually decreased from base line. This pressure change coordinated with gallbladder.(Conclusion) Newly developed microtransducer catheter provides additional information of the biliary tract. Our result indicated that CBD pressure had close relationship gallbladder contractions and CBD pressure change was observed in the postprandial state.