Effect of traditional Japanese medicine (Kampo) to cisplatin induced abnormal digestive contractions -Rikkunshito and ghrelin-

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Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 hours. 5HT3 receptor antagonist inhibited cisplatin induced an abnormal motor activity, but Rikkunshito did not inhibit it. The 5-HT concentration in plasma reached a peak at 4 hours after cisplatin administration. In a fasting state, intragastric administration of rikkunshito induced phasic contractions in the duodenum and jejunum in normal dogs. Rikkunshito-induced contractions were inhibited by atropine and hexamethonium. Gastric emptying was accelerated by intragastric administration of rikkunshito in a dose-dependent manner. The plasma acylated ghrelin level 150 min after intragastric administration of4.0 g of rikkunshito was significantly higher than the control value. These findings indicate that the contractile effect of rikkunshito is mediated by cholinergic neurons and that 5-HT3 receptors have apartial role in this action.