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Effect of traditional Japanese medicine (Kampo) to cisplatin induced abnormal digestive contractions -Rikkunshito and ghrelin-

传统日本药物（汉方）对顺铂引起的消化道收缩异常的影响-六君子和胃饥饿素-

基本信息

批准号：
22591449
负责人：
MOCHIKI Erito
金额：
$ 2.5万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 hours. 5HT3 receptor antagonist inhibited cisplatin induced an abnormal motor activity, but Rikkunshito did not inhibit it. The 5-HT concentration in plasma reached a peak at 4 hours after cisplatin administration. In a fasting state, intragastric administration of rikkunshito induced phasic contractions in the duodenum and jejunum in normal dogs. Rikkunshito-induced contractions were inhibited by atropine and hexamethonium. Gastric emptying was accelerated by intragastric administration of rikkunshito in a dose-dependent manner. The plasma acylated ghrelin level 150 min after intragastric administration of4.0 g of rikkunshito was significantly higher than the control value. These findings indicate that the contractile effect of rikkunshito is mediated by cholinergic neurons and that 5-HT3 receptors have apartial role in this action.

静脉注射顺铂产生异常运动活动，持续长达5小时。5-HT_3受体拮抗剂能抑制顺铂引起的异常运动活动，而力健志东不能抑制，给药后4 h血浆中5-HT浓度达高峰。在禁食状态下，灌胃给予力健素诱导正常犬十二指肠和空肠的阶段性收缩。Rikkunshito引起的收缩被阿托品和六甲双铵抑制。胃内给予力坤师托以剂量依赖性方式加速胃排空。灌胃给予4.0 g力健素后150 min，血浆酰化ghrelin水平显著高于对照值。这些结果表明，力坤脂的收缩作用是由胆碱能神经元介导的，5-HT_3受体在这一作用中起部分作用。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

消化管運動と漢方、特集消化器疾患と漢方

胃肠动力与中医，胃肠疾病与中医专题

DOI：
发表时间：
2010
期刊：
G.I.research
影响因子：
0
作者：
持木彫人;桑野博行
通讯作者：
桑野博行

Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans.

DOI：
10.2147/ceg.s26297
发表时间：
2011
期刊：
Clinical and experimental gastroenterology
影响因子：
2.4
作者：
Ohno T;Yanai M;Ando H;Toyomasu Y;Ogawa A;Morita H;Ogata K;Mochiki E;Asao T;Kuwano H
通讯作者：
Kuwano H

Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs