Clinical basic research for the surgical treatment of the cervical carotid artery stenosis.

本研究旨在探讨颈动脉狭窄的临床病理特点。尤其是关于肝素辅因子II和血小板聚集的病理学意义。在两年的研究期间，发现了以下四个方面的新证据，并报道了重要的主题。1颈动脉分叉处动脉壁变化的典型病理表现：弹性/肌肉动脉变化与动脉斑块范围限制的关系。这些发现将为外科和血管内治疗策略提供重要信息。2肝素辅因子II的生理和病理机制。3神经血管内治疗或血管造影术患者的血小板聚集和肝素激活的监测。在这些研究的基础上，我们继续研究，以调查颈动脉疾病的真实病理特征，并创造最合适的治疗选择和方法。

The purpose of this study is to approach clinical-pathological feature of the carotid artery stenosis, ; especially about the arterial wall characteristics, and pathological meaning of heparin cofactor II and platelet aagregation,.During 2 year research periods, the following four subjects were revealed as new evidence in this field, and important topics were reported in the journal.1 Characteristic pathological findings of the arterial wall changes at the carotid bifurcation : relationship of the changes the elastic/muscular artery and limitation of the atheroma plaque extention.These findings should reveal important information for surgical and endovascular treatment strategy.2 Physiological and pathological mechanisms of heparin cofactor II.3 Monitoring of platelet aggregation and heparin activation in patients undergoing neuroendovascular treatment or angiography.Based on these studies, we continued research to investigate true pathological features of the carotid artery disease and to create the most adequate treatment selection and methods.