Basic Research of carcinogenesis and cancer prevention (carcinogenesis)

我们发现，细胞周期调节的失调或破坏以及所谓的DNA交易，如DNA复制、修复和重组，导致了基因组在几个特定区域的不稳定。自从发现癌基因以来，人们普遍认为转录失调也是肿瘤发生的基础。该研究机构的研究人员已经积累了大量与转录相关的结果，显示了通过形成大型蛋白质复合物、染色质的组装和重塑、组蛋白乙酰化和去乙酰化等转录调控所需的大量分子。在过去的6年里，我们取得了11项最重要的研究成果。奈梅亨综合征、V型色素性干皮病及相关框移突变基因的鉴定Runt结构域转录因子PEBP2在造血、白血病发生和成骨中的作用鉴定。EVB在胃癌中的作用。大鼠家族性肾癌致Tsc-2的鉴定。表达HCV核心基因的转基因小鼠肝癌的诱导。致癌基因ski和no也有抑制肿瘤的作用。一种新的基因诱捕方法的发展。结肠癌中前列腺素受体的鉴定。10.环境致癌性风险评估标准的建立。Cajal肠系膜肿瘤相关细胞类型的鉴定。流行病学的重大进展。

We found that dysregulation or breakdown of cell cycle regulation and so-called DNA transactions, such as DNA replication, repair and recombination, contribute to the genome instability in several specific areas. Since the discovery of oncogenes, it is a common belief that dysregnlation of transcription is also a basis of oncogenesis. A large body of transcription-related results have been accumulated showing a large number of molecules required for transcriptional regulation by forming a large protein complexes, assembly and remodeling of chromatin, histone acetylation and deacetylation by researchers in this research organization. Eleven most significant research accomplishments made in the past 6 ycars are listed below :1. Identification of the genes responsible for Nijmegen syndrome, xeroderma pigmentosus type V and related frame shift mutator.2. Identification of the roles of the Runt domain transcription factor PEBP2 in hematopoiesis, leukemogenesis and osteogenesis.3. Involvement of EVB in gastric cancer.4. Identification of Tsc-2 responsible for familial cancer of rat kidney.5. Induction of liver cancer in transgenic mouse expressing HCV core gene.6. Oncogenes ski and sno also act as tumor suppressors.7. Development of a new gene trap method.8. Identification of receptors for prostanoid involved in colon cancer.9. Establishment of standard for risk assessment for environmental carcinogenesis.10. Identification of the cell type of those involved in Cajal mesenteric tumors.11. Significant advancement in epidemiology.