Coordination Funds

该研究单位的目标是开发和验证一种集成解决方案，用于颌面外科增材制造植入物的制造，表征和基于模拟的设计，同时考虑到个体骨骼情况的生理条件。因此，需要一个整体的资格认证方法，以及材料科学与工程，医学工程和数值模拟的跨学科考虑。在此基础上，新的和基于机制的体外和体内测试方法，包括多尺度模拟和建模方法（在硅片上），由跨学科联盟实施，以描述机械，生物和腐蚀过程及其相互作用。由于目前设想的研究课题的多样性和复杂性，必须由年轻科学家在有经验的研究人员的监督下进行跨学科处理。所追求的科学问题的复杂性将逐步增加。在第一个资助期内（FP-1：第1 - 4年），将表征钛制永久性植入物的机械-生物学行为。作为补充，腐蚀机制对镁制成的生物可吸收植入物的机械-生物学行为的影响将在第二个资助期（FP-2：第5 - 8年）面临。总之，可确定以下总体目标：1）通过考虑特定的骨结构和可能的骨缺损，进行患者个性化的植入物设计（例如，防止骨增量）2）通过使用晶格结构局部调节刚度来最小化植入物-骨界面内的应力屏蔽，以实现成功的组织整合3）表征晶格结构化对诸如微结构、缺损形成和形貌的量的影响，4）通过表面处理改变材料的表面形貌和性能（例如喷砂）和涂层（例如，PEM涂层）以刺激组织整合5）机械的时间和资源有效的模拟和建模，生物学和腐蚀性剖面，6）开发一种时间和资源有效的基于实验和模拟的表征方法以提高质量，因此也提高了长期存活率，并加快了未来植入物的开发和鉴定周期。

Aim of the research unit will be the development and validation of an integrated solution for the manufacturing, characterization and simulation-based design of additively manufactured implants in maxillofacial surgery, taking into account physiological conditions of the individual bone situation. Therefore, a holistic qualification approach, as well as an interdisciplinary consideration of materials science and engineering, medical engineering and numeric simulation, is required. Based on this, novel and mechanism-based in vitro and in vivo testing methods, including multi-scale simulation and modeling methods (in silico), are implemented by the interdisciplinary consortium in order to describe the mechanical, biological and corrosive processes and their interactions. Due to the present diversity and complexity of the envisaged research topic, interdisciplinary processing by young scientists, supervised by proven researchers, is mandatory. The complexity of the pursued scientific issues will be increased stepwise. Within the first funding period (FP-1: 1st to 4th year) the mechanical-biological behavior of permanent implants made of titanium will be characterized. Supplementary, the effect of corrosion mechanisms on the mechanical-biological behavior of bioresorbable implants made of magnesium will be faced in the second funding period (FP-2: 5th to 8th year). In summary, the following overall objectives can be defined:1) Patient-individualized implant design by considering specific bone structures and possible bone defects (e.g. prevention of bone augmentation)2) Minimization of stress-shielding within implant-bone interface through local adjustment of stiffness by using lattice structures for a successful tissue integration3) Characterization of the influence of lattice structuring on quantities such as microstructure, defects formation and topography, and the correlation with the corresponding property profile4) Modification of surface morphology and properties through surface treatment (e.g. sandblasting) and coating (e.g. PEM coatings) in order to stimulate tissue integration5) Time- and resource-efficient simulation and modeling of the mechanical, biological and corrosive property profile via multi-scale approaches by linking multiple levels of scalability with the aid of artificial neuronal networks6) Development of a time- and resource-efficient experimental and simulation-based characterization methodology to increase the quality, consequently also the long-term survival rate and to accelerate the development and qualification period for future implants.