Experimentally validated multiphase mathematical models of leg ulcers

该项目旨在开发腿部溃疡形成和愈合的复杂生物过程的数学模型。该项目旨在结合流体力学、数学生物学、数值分析和统计推理的数学技术，开发新的、多阶段的、经过验证的数学模型，以捕捉腿部溃疡形成和愈合过程中细胞和化学物种的复杂时空演变--目前对此知之甚少的生物过程。这些数学模型有望为腿部溃疡的潜在生物学机制提供新的见解，并最终可能改善慢性伤口的管理。

The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the formation and healing of a leg ulcer – biological processes which are currently poorly understood. The mathematical models are expected to provide new insight into the underlying biological mechanisms of leg ulcers and may ultimately improve management of chronic wounds.