Advanced Brain Science Project

通过这个项目，发表了许多影响最大的论文，清楚地表明了日本的神经科学水平很高。当该项目在2000年启动时，为每个领域设定了目标，我相信我们所有人都已经实现了这些目标。在优秀的出版物中，以下是特别的：M.Nakafuku博士的《Brain Repair》；K.Kaibuhi博士的指导分子的鉴定；T.Saido博士的Neprilysin作为AB降解酶的发现；G.Sobue博士的一种治疗X连锁脊髓和延髓肌肉萎缩的新药的临床试验。此外，值得一提的是J.Tanji博士在利用猴子进行高级皮质功能研究方面的稳步进展。最后，确定阿尔茨海默病的一个易感基因是日本这类研究的一个里程碑。人们经常声称，需要跨学科的互动才能显著推动科学发展，事实上，这个项目提供了这样的机会。这在一定程度上可以解释为什么A01研究人员获得了最引人注目的数据：一般情况下，从事发育、神经生物学和干细胞专业的优秀研究人员聚集在神经发生的旗帜下，并相互之间进行了密切的互动。

By this project, many papers with the highest impact have been published, which have clearly shown that the level of neuroscience in Japan is very high. When the project was initiated in 2000, goals were set for each field, and I believe all of us have reached them. Among the excellent publications, the following ones are exceptional: "Brain repair" by Dr. M. Nakafuku; identification of guidance molecules by Dr. K. Kaibuchi, discovery of neprilysin as a AB-degrading protease by Dr. T. Saido, and clinical trial of a new drug for X-linked spinal and bulbar muscular atrophy by Dr. G. Sobue. In addition, steady progress in the research of higher cortical function using monkey by Dr. J. Tanji should be mentioned here. Finally, identification of one susceptibility gene for Alzheimer's disease is a milestone in this kind of research in Japan.It is often claimed that interdisciplinary interaction is required to significantly advance science, and indeed this project provided such opportunity. This can partly explain why A01 investigators have obtained the most striking data: excellent investigators majoring development in general, neurobiology and stem cells have got together under the flag of neurogenesis, and heavily interacted with each another.