Investigation on pathological implications of guidance molecules in neuro-immune-metabolism.

神经免疫代谢中引导分子的病理学意义的研究。

• 批准号: 18H05282
• 负责人: Kumanogoh Atsushi
• 金额: $ 122.97万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-06-11 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H05282/
• 关键词: 神経免疫代謝連関; 神経ガイダンス; セマフォリン; 神経免疫代謝; 免疫代謝; 神経・免疫・代謝; ガイダンス因子; 神経免疫クロストーく; 神経免疫クロストーク; 慢性炎症; 神経ガイダンス因子; 神経疾患; 免疫疾患

项目成果

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.

• DOI: 10.1038/s41588-023-01375-1
• 发表时间: 2023-05
• 期刊: NATURE GENETICS
• 影响因子: 30.8
• 作者: Edahiro, Ryuya;Shirai, Yuya;Takeshima, Yusuke;Sakakibara, Shuhei;Yamaguchi, Yuta;Murakami, Teruaki;Morita, Takayoshi;Kato, Yasuhiro;Liu, Yu-Chen;Motooka, Daisuke;Naito, Yoko;Takuwa, Ayako;Sugihara, Fuminori;Tanaka, Kentaro;Wing, James B.;Sonehara, Kyuto;Tomofuji, Yoshihiko;Namkoong, Ho;Tanaka, Hiromu;Lee, Ho;Fukunaga, Koichi;Hirata, Haruhiko;Takeda, Yoshito;Okuzaki, Daisuke;Kumanogoh, Atsushi;Okada, Yukinori;Wang, Qingbo S.;Edahiro, Ryuya;Namkoong, Ho;Hasegawa, Takanori;Shirai, Yuya;Sonehara, Kyuto;Tanaka, Hiromu;Lee, Ho;Saiki, Ryunosuke;Hyugaji, Takayoshi;Shimizu, Eigo;Katayama, Kotoe;Kanai, Masahiro;Naito, Tatsuhiko;Sasa, Noah;Yamamoto, Kenichi;Kato, Yasuhiro;Morita, Takayoshi;Takahashi, Kazuhisa;Harada, Norihiro;Naito, Toshio;Hiki, Makoto;Matsushita, Yasushi;Takagi, Haruhi;Ichikawa, Masako;Nakamura, Ai;Harada, Sonoko;Sandhu, Yuuki;Kabata, Hiroki;Masaki, Katsunori;Kamata, Hirofumi;Ikemura, Shinnosuke;Chubachi, Shotaro;Okamori, Satoshi;Terai, Hideki;Morita, Atsuho;Asakura, Takanori;Sasaki, Junichi;Morisaki, Hiroshi;Uwamino, Yoshifumi;Nanki, Kosaku;Uchida, Sho;Uno, Shunsuke;Nishimura, Tomoyasu;Ishiguro, Takashi;Isono, Taisuke;Shibata, Shun;Matsui, Yuma;Hosoda, Chiaki;Takano, Kenji;Nishida, Takashi;Kobayashi, Yoichi;Takaku, Yotaro;Takayanagi, Noboru;Ueda, Soichiro;Tada, Ai;Miyawaki, Masayoshi;Yamamoto, Masaomi;Yoshida, Eriko;Hayashi, Reina;Nagasaka, Tomoki;Arai, Sawako;Kaneko, Yutaro;Sasaki, Kana;Tagaya, Etsuko;Kawana, Masatoshi;Arimura, Ken;Takahashi, Kunihiko;Anzai, Tatsuhiko;Ito, Satoshi;Endo, Akifumi;Uchimura, Yuji;Miyazaki, Yasunari;Honda, Takayuki;Tateishi, Tomoya;Tohda, Shuji;Ichimura, Naoya;Sonobe, Kazunari;Sassa, Chihiro Tani;Nakajima, Jun;Nakano, Yasushi;Nakajima, Yukiko;Anan, Ryusuke;Arai, Ryosuke;Kurihara, Yuko;Harada, Yuko;Nishio, Kazumi;Ueda, Tetsuya;Azuma, Masanori;Saito, Ryuichi;Sado, Toshikatsu;Miyazaki, Yoshimune;Sato, Ryuichi;Haruta, Yuki;Nagasaki, Tadao;Yasui, Yoshinori;Hasegawa, Yoshinori;Mutoh, Yoshikazu;Kimura, Tomoki;Sato, Tomonori;Takei, Reoto;Hagimoto, Satoshi;Noguchi, Yoichiro;Yamano, Yasuhiko;Sasano, Hajime;Ota, Sho;Nakamori, Yasushi;Yoshiya, Kazuhisa;Saito, Fukuki;Yoshihara, Tomoyuki;Wada, Daiki;Iwamura, Hiromu;Kanayama, Syuji;Maruyama, Shuhei;Yoshiyama, Takashi;Ohta, Ken;Kokuto, Hiroyuki;Ogata, Hideo;Tanaka, Yoshiaki;Arakawa, Kenichi;Shimoda, Masafumi;Osawa, Takeshi;Tateno, Hiroki;Hase, Isano;Yoshida, Shuichi;Suzuki, Shoji;Kawada, Miki;Horinouchi, Hirohisa;Saito, Fumitake;Mitamura, Keiko;Hagihara, Masao;Ochi, Junichi;Uchida, Tomoyuki;Baba, Rie;Arai, Daisuke;Ogura, Takayuki;Takahashi, Hidenori;Hagiwara, Shigehiro;Nagao, Genta;Konishi, Shunichiro;Nakachi, Ichiro;Murakami, Koji;Yamada, Mitsuhiro;Sugiura, Hisatoshi;Sano, Hirohito;Matsumoto, Shuichiro;Kimura, Nozomu;Ono, Yoshinao;Baba, Hiroaki;Suzuki, Yusuke;Nakayama, Sohei;Masuzawa, Keita;Namba, Shinichi;Shiroyama, Takayuki;Noda, Yoshimi;Niitsu, Takayuki;Adachi, Yuichi;Enomoto, Takatoshi;Amiya, Saori;Hara, Reina;Yamaguchi, Yuta;Murakami, Teruaki;Kuge, Tomoki;Matsumoto, Kinnosuke;Yamamoto, Yuji;Yamamoto, Makoto;Yoneda, Midori;Tomono, Kazunori;Kato, Kazuto;Hirata, Haruhiko;Takeda, Yoshito;Koh, Hidefumi;Manabe, Tadashi;Funatsu, Yohei;Ito, Fumimaro;Fukui, Takahiro;Shinozuka, Keisuke;Kohashi, Sumiko;Miyazaki, Masatoshi;Shoko, Tomohisa;Kojima, Mitsuaki;Adachi, Tomohiro;Ishikawa, Motonao;Takahashi, Kenichiro;Inoue, Takashi;Hirano, Toshiyuki;Kobayashi, Keigo;Takaoka, Hatsuyo;Watanabe, Kazuyoshi;Miyazawa, Naoki;Kimura, Yasuhiro;Sado, Reiko;Sugimoto, Hideyasu;Kamiya, Akane;Kuwahara, Naota;Fujiwara, Akiko;Matsunaga, Tomohiro;Sato, Yoko;Okada, Takenori;Hirai, Yoshihiro;Kawashima, Hidetoshi;Narita, Atsuya;Niwa, Kazuki;Sekikawa, Yoshiyuki;Nishi, Koichi;Nishitsuji, Masaru;Tani, Mayuko;Suzuki, Junya;Nakatsumi, Hiroki;Ogura, Takashi;Kitamura, Hideya;Hagiwara, Eri;Murohashi, Kota;Okabayashi, Hiroko;Mochimaru, Takao;Nukaga, Shigenari;Satomi, Ryosuke;Oyamada, Yoshitaka;Mori, Nobuaki;Baba, Tomoya;Fukui, Yasutaka;Odate, Mitsuru;Mashimo, Shuko;Makino, Yasushi;Yagi, Kazuma;Hashiguchi, Mizuha;Kagyo, Junko;Shiomi, Tetsuya;Fuke, Satoshi;Saito, Hiroshi;Tsuchida, Tomoya;Fujitani, Shigeki;Takita, Mumon;Morikawa, Daiki;Yoshida, Toru;Izumo, Takehiro;Inomata, Minoru;Kuse, Naoyuki;Awano, Nobuyasu;Tone, Mari;Ito, Akihiro;Nakamura, Yoshihiko;Hoshino, Kota;Maruyama, Junichi;Ishikura, Hiroyasu;Takata, Tohru;Odani, Toshio;Amishima, Masaru;Hattori, Takeshi;Shichinohe, Yasuo;Kagaya, Takashi;Kita, Toshiyuki;Ohta, Kazuhide;Sakagami, Satoru;Koshida, Kiyoshi;Hayashi, Kentaro;Shimizu, Tetsuo;Kozu, Yutaka;Hiranuma, Hisato;Gon, Yasuhiro;Izumi, Namiki;Nagata, Kaoru;Ueda, Ken;Taki, Reiko;Hanada, Satoko;Kawamura, Kodai;Ichikado, Kazuya;Nishiyama, Kenta;Muranaka, Hiroyuki;Nakamura, Kazunori;Hashimoto, Naozumi;Wakahara, Keiko;Koji, Sakamoto;Omote, Norihito;Ando, Akira;Kodama, Nobuhiro;Kaneyama, Yasunari;Maeda, Shunsuke;Kuraki, Takashige;Matsumoto, Takemasa;Yokote, Koutaro;Nakada, Taka-Aki;Abe, Ryuzo;Oshima, Taku;Shimada, Tadanaga;Harada, Masahiro;Takahashi, Takeshi;Ono, Hiroshi;Sakurai, Toshihiro;Shibusawa, Takayuki;Kimizuka, Yoshifumi;Kawana, Akihiko;Sano, Tomoya;Watanabe, Chie;Suematsu, Ryohei;Sageshima, Hisako;Yoshifuji, Ayumi;Ito, Kazuto;Takahashi, Saeko;Ishioka, Kota;Nakamura, Morio;Masuda, Makoto;Wakabayashi, Aya;Watanabe, Hiroki;Ueda, Suguru;Nishikawa, Masanori;Chihara, Yusuke;Takeuchi, Mayumi;Onoi, Keisuke;Shinozuka, Jun;Sueyoshi, Atsushi;Nagasaki, Yoji;Okamoto, Masaki;Ishihara, Sayoko;Shimo, Masatoshi;Tokunaga, Yoshihisa;Kusaka, Yu;Ohba, Takehiko;Isogai, Susumu;Ogawa, Aki;Inoue, Takuya;Fukuyama, Satoru;Eriguchi, Yoshihiro;Yonekawa, Akiko;Kan-o, Keiko;Matsumoto, Koichiro;Kanaoka, Kensuke;Ihara, Shoichi;Komuta, Kiyoshi;Inoue, Yoshiaki;Chiba, Shigeru;Yamagata, Kunihiro;Hiramatsu, Yuji;Kai, Hirayasu;Asano, Koichiro;Oguma, Tsuyoshi;Ito, Yoko;Hashimoto, Satoru;Yamasaki, Masaki;Kasamatsu, Yu;Komase, Yuko;Hida, Naoya;Tsuburai, Takahiro;Oyama, Baku;Takada, Minoru;Kanda, Hidenori;Kitagawa, Yuichiro;Fukuta, Tetsuya;Miyake, Takahito;Yoshida, Shozo;Ogura, Shinji;Abe, Shinji;Kono, Yuta;Togashi, Yuki;Takoi, Hiroyuki;Kikuchi, Ryota;Ogawa, Shinichi;Ogata, Tomouki;Ishihara, Shoichiro;Kanehiro, Arihiko;Ozaki, Shinji;Fuchimoto, Yasuko;Wada, Sae;Fujimoto, Nobukazu;Nishiyama, Kei;Terashima, Mariko;Beppu, Satoru;Yoshida, Kosuke;Narumoto, Osamu;Nagai, Hideaki;Ooshima, Nobuharu;Motegi, Mitsuru;Umeda, Akira;Miyagawa, Kazuya;Shimada, Hisato;Endo, Mayu;Ohira, Yoshiyuki;Watanabe, Masafumi;Inoue, Sumito;Igarashi, Akira;Sato, Masamichi;Sagara, Hironori;Tanaka, Akihiko;Ohta, Shin;Kimura, Tomoyuki;Shibata, Yoko;Tanino, Yoshinori;Nikaido, Takefumi;Minemura, Hiroyuki;Sato, Yuki;Yamada, Yuichiro;Hashino, Takuya;Shinoki, Masato;Iwagoe, Hajime;Takahashi, Hiroshi;Fujii, Kazuhiko;Kishi, Hiroto;Kanai, Masayuki;Imamura, Tomonori;Yamashita, Tatsuya;Yatomi, Masakiyo;Maeno, Toshitaka;Hayashi, Shinichi;Takahashi, Mai;Kuramochi, Mizuki;Kamimaki, Isamu;Tominaga, Yoshiteru;Ishii, Tomoo;Utsugi, Mitsuyoshi;Ono, Akihiro;Tanaka, Toru;Kashiwada, Takeru;Fujita, Kazue;Saito, Yoshinobu;Seike, Masahiro;Watanabe, Hiroko;Matsuse, Hiroto;Kodaka, Norio;Nakano, Chihiro;Oshio, Takeshi;Hirouchi, Takatomo;Makino, Shohei;Egi, Moritoki;Omae, Yosuke;Nannya, Yasuhito;Ueno, Takafumi;Takano, Tomomi;Katayama, Kazuhiko;Ai, Masumi;Kumanogoh, Atsushi;Sato, Toshiro;Hasegawa, Naoki;Tokunaga, Katsushi;Ishii, Makoto;Koike, Ryuji;Kitagawa, Yuko;Kimura, Akinori;Imoto, Seiya;Miyano, Satoru;Ogawa, Seishi;Kanai, Takanori;Fukunaga, Koichi
• 通讯作者: Fukunaga, Koichi

Rapid attenuation of anti-SARS-CoV-2 antibodies in patients with musculoskeletal diseases in whom intensive immunosuppressive therapies were reinitiated after COVID-19: comment on the article by Curtis et al

在 COVID-19 后重新开始强化免疫抑制治疗的肌肉骨骼疾病患者中，抗 SARS-CoV-2 抗体迅速减弱：对 Curtis 等人文章的评论

• DOI: 10.1002/art.42003
• 发表时间: 2022
• 期刊: Arthritis and Rheumatology
• 影响因子: 13.3
• 作者: Okamoto Masashi;Kawada Shoji;Shimagami Hiroshi;Fujii Naoko;Matsukawa Kazuki;Ishikawa Nachi;Kawamoto Keisuke;Higa Shinji;Ishida Yutaka;Ogata Atsushi;Yamaguchi Yuta;Morita Takayoshi;Kato Yasuhiro;Kumanogoh Atsushi
• 通讯作者: Kumanogoh Atsushi

Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells

• DOI: 10.1172/jci.insight.123093
• 发表时间: 2018-12-20
• 期刊: JCI INSIGHT
• 影响因子: 8
• 作者: Kinehara, Yuhei;Nagatomo, Izumi;Kumanogoh, Atsushi
• 通讯作者: Kumanogoh, Atsushi

Pathological involvement of semaphorins in immunological disorders.

信号蛋白在免疫疾病中的病理学参与。

• 发表时间: 2022
• 作者: 李誠鎬;春日敏宏;中野貴由;Atsushi Kumanogoh
• 通讯作者: Atsushi Kumanogoh

Direct activation of microglia by β-glucosylceramide causes phagoptosis of neurons that exacerbates Gaucher disease.

β-葡萄糖神经酰胺直接激活小胶质细胞会导致神经元吞噬细胞凋亡，从而加重戈谢病。

• DOI: 10.1016/j.immuni.2023.01.008
• 发表时间: 2023
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Shimizu T;Schutt C R;Izumi Y;Tomiyasu N;Omahdi Z;Kano K;Takamatsu H;Aoki J;Bamba T;Kumanogoh A;Takao M;Yamasaki S*.
• 通讯作者: Yamasaki S*.