Cancer epidemiological studies for Japanese immigrants and development of preventive strategy for cancer based on the evidence from the studies

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We have conducted epidemiological studies such as cross-sectional and case-control study among Japanese Brazilians living in Sao Paulo. In case-control studies for breast cancer, we analyzed data from in three populations : Japanese living in Japan, Japanese Brazilians living in Sao Paulo, and non-Japanese Brazilians living in Sao Paulo. We found an inverse association between isoflavone intake and breast cancer risk, and stratified analysis suggested that polymorphisms in the estrogen receptor beta, 17β-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. We found no overall association between folate, vitamin B6, and vitamin B12 intake and the risk of breast cancer. In a cross-sectional study of colorectal adenoma among Japanese Brazilians living in Sao Paulo, Brazil, participants have been recruited in two hospitals and we completed a survey from 719 participates at the end of March, 2010.