Analysis in pathogenesis of bacterial lethal soft-tissue infection and application to prevention and therapy.

对于产气荚膜梭菌和化脓性链球菌，我们通过基因组测序和DNA芯片实验进行了全面的分析，这两种细菌都能引起严重的软组织感染（食肉细菌）。我们发现这两种细菌都有共同的机制，使用小的非编码RNA来控制毒力表达，但两者都有不同的独特的基因组维持机制和毒力控制的总调控系统。这些研究对于寻找预防和/或治疗的分子靶点具有重要意义，这将导致新的细菌感染控制的创新。

In Clostridium perfringens and Streptococcus pyogenes, both of which causes severe soft-tissue infection (flesh-eating bacteria), we proceed comprehensive analyses by genome sequencing and DNA microarray experiments. We found that these bacteria share common mechanism using small non-coding RNA for the control of virulence expression and that both have different unique mechanism for genome maintenance and total regulatory system for virulence control. These research would be important for finding molecular targets for prevention and/or therapy, which will lead to the innovation of new bacterial infection control.