Establishment of Bio-nanotool for Local-environmental Measurement and Control by Nano-assembly System

近年来，生物系统的分析与控制，特别是对作为生物系统原始单位之一的生物细胞的分析与控制得到了广泛的研究。重要的技术是动态地控制和观察它们的局部环境。然而，电化学梯度、离子浓度等的高精度测量，目前在纳米尺度上基本上是困难的。此外，还需要对其物理/化学性质进行低/无创测量技术。本研究结合材料科学、测量/控制/制造技术，建立了基于纳米操作技术的生物纳米工具，用于测量和控制生物细胞的局部环境。将纳米尺度的生物纳米工具应用于微米尺度的生物细胞，提出了一种新的局部环境测控技术。

Recently, analysis and control of biological system, especially for biological cell which is one of the primitive units of biological system, have been widely investigated. The important technique is to control and observe their local environment dynamically. However, the high precision measurement of electrochemical gradient, ionic concentration, and so on, is basically difficult in nano-scale until now. And, low/noninvasive measurement techniques for their physical/chemical properties are also needed.In this research, we established bio-nanotools to measure and control the local environment of biological cells based on nanomanipulation technique by integrating material science, measurement/control/fabrication technologies. We proposed novel local environmental measurement and control technique by applying nano-meter scale bio-nanotools to micro-meter scale biological cell.