Organic solute transportsomes: their molecular assembly and functional significance
Organic solute transportsomes: their molecular assembly and functional significance
批准号:
17081016
负责人:
KANAI Yoshikatsu
金额:
$62.53万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
本研究的目的是建立“运输性”的概念。最后,本研究旨在展示转运体对应的分子组装并揭示其功能意义。本研究通过证明由支架蛋白形成的转运体的分子组装和揭示涉及转运体和酶的新型转运体的概念来完成,所述转运体和酶通过给予和接受底物和桥接彼此面对的膜而偶联。
英文摘要
The purpose of this research was to establish the idea of "transportsome". Toward its end, this research directed to demonstrate the molecular assembly corresponding to transportsome and to reveal its functional significance. This research has been completed by establishing the idea of "transportsome" by demonstrating the molecular assembly of the transportsomes formed by scaffold proteins and by reveling new types of transportsomes involving transporters and enzymes coupled by giving and taking the substrates and ones bridging membranes facing with each other.
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DOI:
10.1111/j.1440-1827.2008.02319.x
发表时间:
2009-01-01
期刊:
PATHOLOGY INTERNATIONAL
影响因子:
2.2
作者:
[Sakata, Takeshi, Ferdous, Golam, Okayasu, Isao]
通讯作者:
Okayasu, Isao
DOI:
10.1248/bpb.31.1096
发表时间:
2008-06-01
期刊:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子:
2
作者:
[Kim, Chun Sung, Cho, Seon-Ho, Kim, Do Kyung]
通讯作者:
Kim, Do Kyung
Renal elimination of p-aminohippurate (PAH) in respose to three days of biliary obstruction in the rat. The role of OAT1 and OAT3.
肾脏消除对氨基马尿酸(PAH)以应对大鼠三天的胆道阻塞。
DOI:
--
发表时间:
2006
期刊:
Biochim Biophys Acta. 1762
影响因子:
--
作者:
[Brandoni A, et al.]
通讯作者:
et al.
栄養による固体機能制御と疾患 アミノ酸トランスポーターと癌
营养诱导的固态功能和疾病的调节氨基酸转运蛋白和癌症
DOI:
--
发表时间:
2009
期刊:
細胞工学 28
影响因子:
--
作者:
[久々宇郁也, 高田龍平, 高砂織, 鈴木洋史, 金井好克]
通讯作者:
金井好克
上皮体制と病態
上皮系统和病理学
DOI:
--
发表时间:
2009
期刊:
腎臓 32
影响因子:
--
作者:
[Kurokawa J, Furukawa T., 金井好克]
通讯作者:
金井好克
共 161 条
Regulation of cellular metabolism and functions mediated by amino acid transporters and the mechanisms of action of their inhibitors
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批准号:15H04685
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2015
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负责人:KANAI Yoshikatsu
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依托单位:
Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway
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财政年份:2012
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负责人:KANAI Yoshikatsu
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依托单位:
Signaling mechanisms of a novel-type transmembrane receptor 4F2hc
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批准号:22659052
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.98万
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财政年份:2010
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负责人:KANAI Yoshikatsu
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依托单位:
Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
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批准号:21390264
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2009
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负责人:KANAI Yoshikatsu
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依托单位:
Identification and functional characterization of plasma membrane amino acid sensors
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批准号:19590256
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:KANAI Yoshikatsu
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依托单位:
Study on_the protein-protein interaction regulating the function of amino acid transporters
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批准号:17590226
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KANAI Yoshikatsu
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依托单位:
Transportsome on biomembrane systems: its molecular assembly and physiological function.
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批准号:17081015
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$15.1万
-
财政年份:2005
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负责人:KANAI Yoshikatsu
-
依托单位:
Identification and functional characterization of all the genes of heterodimeric amino acid transporter family by means of whole genome information
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批准号:14570085
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
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财政年份:2002
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负责人:KANAI Yoshikatsu
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依托单位:
Molecular mechanisms of drug transports via amino acid transporters
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批准号:12670095
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2000
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负责人:KANAI Yoshikatsu
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依托单位:
Cloning of transporters for anionic drugs and the application to pharmacokinetic analysis
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批准号:11557005
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:1999
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负责人:KANAI Yoshikatsu
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依托单位:
Molecular mechanisms of the organic anion permeation through blood-brain barrier
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批准号:10670096
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1998
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负责人:KANAI Yoshikatsu
-
依托单位:
Roles of glutamate transporters in the nervous system
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批准号:07044292
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$3.01万
-
财政年份:1995
-
负责人:KANAI Yoshikatsu
-
依托单位:
Molecular identification of cystine / glutamate exchanger
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批准号:07670117
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1995
-
负责人:KANAI Yoshikatsu
-
依托单位:
海外基金