Coordination Funds

抽动-秽语综合征（GTS）是一种常见的多方面神经精神障碍，以运动性和发声性抽动（包括回声和粪便现象）为主要临床特征。尽管对GTS儿童和成人进行了大量的神经科学研究，但尚未出现普遍接受的抽搐或GTS概念。在第一个资助期内，我们研究了一个概念框架的适用性（即，事件编码理论）来概念化GTS中的tics和其他相关现象。我们可以证实我们的主要假设，即GTS的特点是感知和动作过程的超结合，这种改变是理解GTS的核心。在第二个资助期，我们将在这些结果的基础上，解决与补充项目中研究的四个主要研究领域相关的重要开放问题：（i）我们将研究调节感知-行动结合作为（新）治疗方法的一部分的可行性。(ii)我们将研究如何在缓解期和持续期GTS中调节结合的问题。(iii)我们将讨论绑定与检索过程在GTS患者的感知-动作整合中扮演的角色。(iv)我们还将事件文件的编码机制从社会情感域。在所有的项目中，我们将特别强调对所研究动力学的神经生理过程的研究。第二个资助期旨在为GTS的有效认知理论概念化转移到临床应用奠定基础。

Gilles de la Tourette syndrome (GTS) is a common multifaceted neuropsychiatric disorder with motorand vocal tics including echo- and coprophenomena as cardinal and defining clinical features. Despitean abundance of neuroscientific studies in children and adults with GTS, no generally acceptedconcept of tics or GTS has emerged. In the first funding period, we examined the suitability of acognitive framework (i.e., the Theory of Event Coding) to conceptualize tics and other associatedphenomena in GTS. We could confirm our major hypothesis that GTS can be characterized by ahyperbinding of perception and action processes and that such alterations are central for theunderstanding of GTS. In the second funding period, we will build on these results and will addressimportant open questions that are related to four major research fields examined in complementaryprojects: (i) We will examine the feasibility to modulate perception-action binding as part of (novel)treatment approaches. (ii) We will examine the question of how binding is modulated in remitting vs.persisting GTS. (iii) We will address what role binding vs. retrieval processes play in perception-actionintegration in patients with GTS. (iv) We will also transfer event files coding mechanisms from thecognitive to the socio-affective domain. In all projects, we will put a special emphasis on theinvestigation of neurophysiological processes underlying the examined dynamics. The secondfunding period is intended to establish the basis for a transfer of the validated cognitive-theoreticalconceptualization of GTS into clinical applications.