Regulation of mammalian heart development by transcription factors FHL2, GATA-4 & FOG-2

FHL2参与多种生物学过程，包括细胞内信号转导和基因转录。GATA和FOG蛋白对包括心脏在内的各种组织的发育至关重要。从这个项目中获得的知识将促进我们对许多细胞过程的理解，包括心脏发育，并将有助于我们在生物学、动物学和兽医科学方面的知识。更具体地说，它将有助于干细胞研究，这是生物技术行业的一个“热门”领域，特别是有助于在这一新领域建立强大的专业知识、技能和技术能力基础，甚至可能导致商业产品的开发，例如用于治疗心脏衰竭的心肌细胞涂层生物材料。

FHL2 is involved in many biological processes including intracellular signaling and gene transcription. GATA and FOG proteins are critical for the development of diverse tissues, including the heart. Knowledge gained in this project will advance our understanding of many cellular processes, including heart development, and will contribute to our knowledge in Biology, Zoology and Veterinary Science. More specifically, it will contribute to Stem Cell research, a 'hot' area in the biotechnology industry, particularly towards building a strong base of expertise, skills and technological capability in this new field, and may even lead to the development of a commercial product e.g. a heart muscle cell-coated biomaterial to aid failing heart.