Rapid high-energy (>100 keV) micro-computer tomography

生物医学和材料研究，特别是生物材料，如陶瓷和金属植入物或可吸收和不可吸收重元素（铁、锌、钡和钨）的复合材料，需要精确的高分辨率三维（3D）信息。随着技术的进步，快速、高能量、全包式的独立微型roct仪器正迅速成为研究的标准，特别是具有机械或热载荷的现场测试能力。在这里，我们申请高速高能研究级（离体）微型ct，以支持慈善研究机构多个小组正在进行的广泛研究，特别是DFG资助的研究网络和新的研究人员。该设备，全自动和低维护，将提供给整个研究所的基础和临床研究人员使用新实施的OpenIRIS框架，并将提供适度的预表征和高时间和空间分辨率层析成像数据，这是当今前沿出版物的先决条件。高能x射线源将使研究间隙、裂缝和低密度组织成为可能，例如，高密度假肢/生物材料植入物附近的组织。快速成像将通过高通量闭源+科学级探测器，再加上采用样品处理和多种扫描协议的智能软件来确保，这将有助于达到统计显著性。申请人，高素质和国际知名的材料表征，特别是微和纳米oct成像和量化，将确保机器正常运行时间至少2,500小时/年，并将负责所有调试和用户培训。根据DFG/BMBF/EU >第三方>内部研究资助的优先级列表，申请小组将分享~75%的时间。大约15%的时间将用于即将到来的临床和初级研究人员，其余10%的时间将用于培训和调试共享测量，以开发和维护协议和性能。在微观尺度上成像将有可能揭示一系列生物医学和临床启发组织和结构的不可见方面，跨越CharitéUniversitätsmedizin柏林的10多个部门，使年轻和成熟的研究人员能够以相关的方式提供科学。

Biomedical and materials research, in particular with biomaterials such as ceramicand metal implants or composites of resorbable and non-resorbable heavy elementsspanning Fe, Zn, Ba and W, requires precise high-resolution three-dimensional (3D)information. With advancing technology, rapid, high-energy all-inclusive standalonemicroCT instruments are rapidly becoming standards of research, especially with in-situtesting capabilities of mechanical or thermal loading. Here we apply for a high-speed high-energy research-grade (ex-vivo) microCT to support extensive ongoing research by multiple groups in the Charité research institutes, especially DFG funded research networks and new investigators. The device, fully automatic and low maintenance, will be made available across the institute to both basic and clinical researchers using the newly implemented OpenIRIS framework, and will provide both moderate pre-characterization and high temporal and spatial resolution tomographic data, a pre-requisite for nowadays cutting-edge publications. The high-energy X-ray source will make it possible to study gaps, cracks and low-density tissue e.g. adjacent to high-density prosthetic/biomaterial implants. Rapid imaging will be ensured by a high flux closed source + scientific grade detectors coupled with smart software employing sample manipulation and multi scanning protocols that will ease reaching statistical significance. The applicants, highly qualified and internationally well known for materials characterization and specifically micro and nanoCT imaging and quantification, will ensure machine uptime of at least 2,500 hours/year and will take care of all commissioning and user training. The applying groups will share ~75% of the time based on a priority list according to DFG/BMBF/EU > 3rd party > in-house research grants.Approximately 15% of the total time will be dedicated to upcoming clinical and juniorresearchers and the rest 10% of the time will be used for training and commissioning ofshared measurement to develop and maintain protocols and performance. Imaging at themesoscale will make it possible to reveal invisible aspects of a wide array of biomedical and clinically-inspired tissues and structures across 10+ departments in the CharitéUniversitätsmedizin Berlin, making it possible for young and established researchers todeliver science in a context relevant manner.