Novel Transformations Mediated by the Persistent NO Radical

亚硝基化合物将作为多用途自由基前体用于各种可见光介导的级联反应。重点将放在烷基亚硝基化合物的c自由基光化学生成及其在氧化分子间加成反应中的应用。这些级联是由持久自由基效应控制的，而持久NO自由基介导了这些转化。应用这种新策略将研究亲核、两亲和亲电的c自由基。这些光催化反应具有很高的原子经济性。随着光介导自由基的产生，热变异也将被研究和动力学解决。亚硝基衍生物的光化学sigma键均裂也将应用于杂原子中心自由基的生成。这将大大拓宽本文提出的策略的反应空间。

Nitroso compounds will be used as versatile radical precursors in various visible light mediated cascade reactions. A major focus will lie on the photochemical generation of C-radicals from alkyl nitroso compounds and their application in oxidative intermolecular addition reactions. These cascades are steered by the Persistent Radical Effect and the persistent NO radical mediates the transformations. Nucleophilic, amphiphilic as well as electrophilic C-radicals will be investigated applying this novel strategy. These photo-mediated reactions show high atom economy. Along with the photo-mediated radical generation, thermal variants will also be investigated and kinetics addressed. Photochemical Sigma-bond homolysis in nitroso derivatives will also be applied to the generation of heteroatom-centered radicals. This will significantly broaden the reaction space of the herein proposed strategy.