Porous Capsules' Interactions with Corks and Simultaneously Smaller Entering Cations: Sphere Surface Supramolecular Chemistry and Modeling Biological Cation Transport - Novel Synthetic and NMR Studies

我们的工作重点是独特的氧化钼为基础的多孔胶囊，允许研究纳米级的阳离子分离和动力学，模型细胞（i）跨膜阳离子运输的孔和（ii）设计和微调的空腔，以便提供亲水或疏水的条件，通过适当的配体连接到氧化钼框架。我们打算通过扩展和改进胶囊的内部设备来补充过去两年半中完成的工作，并通过多核NMR，调查和分析细胞内事件的动力学的方法学方面，包括空腔内的客体交换和有机构建块（配体）的内/外“细胞”交换。此外，还打算研究新的现象，例如胶囊内的动态交换平衡。

Our work focuses on unique molybdenum oxide-based porous capsules which allow to study nanoscaled cation separation and dynamics, and model cells with respect to (i) trans-membrane cation transport across the pores and (ii) design and fine-tuning of the cavity, so as to provide hydrophilic or hydrophobic conditions, by attachment of appropriate ligands to the oxidomolybdenum framework. We intend to supplement the work accomplished in the bygone two-and-a-half years by extending and refining the interior equipment of the capsules, and by rarefying, through multinuclear NMR, the methodological aspects of the investigation and the analysis of the dynamics of intracellular incidents, including guest exchange within the cavity and intra/extra-"cellular" exchange of organic building blocks (ligands). Furthermore, it is intended to study new phenomena, e.g. dynamical exchange equilibria within the capsules.