Epidemiology of neurophysiological parameters of the brain using transcranial magnetic stimulation

经颅磁刺激（TMS）能够对人类大脑的兴奋性进行非侵入性和体内研究。尽管在神经临床诊断和神经科学研究中有大量的研究，但迄今为止还没有对大型、具有人口代表性的队列进行系统的流行病学研究。本申请的目的是将经颅磁刺激引入德国最大的流行病学研究之一（波美拉尼亚健康研究SHIP）的新研究人群中。第一次，大脑的兴奋性（主要）和它的促进和抑制（次要）之间的关系将被确定使用简单的tms参数的总数约。2000名参与者。这将是第一次有可能在更大范围内创建与各种个体变量（如年龄、性别或身高）相关的神经生理规范值。这样的队列还可以验证当前对特定神经精神疾病（如头痛和抑郁症）和全身性疾病（如糖尿病）的高度选择人群的研究。因此，结果将有助于更好地理解在诊断常规背景下的个体价值，以及在进一步扩大的神经科学领域。此外，它还推动了神经生理学和治疗方法的发展。

Transcranial magnetic stimulation (TMS) enables a non-invasive and in vivo investigation of the excitability of the human brain. Although used in neurological clinical diagnostics and in neuroscientific research in a large number of studies, no systematic, epidemiological studies on a large, population-representative cohort are available up to date.The aim of this application is to introduce TMS into a new study population of one of the largest epidemiological studies in Germany (Study of Health In Pomerania SHIP). For the first time, the relationship between the excitability of the brain (primary) and its facilitation and inhibition (secondary) will be determined using simple TMS-parameters on a total population of approx. 2000 participants. For the first time it will be possible to create neurophysiological norm values in relation to various individual variables such as age, sex or height on a larger scale. Such a cohort also enables to validate current studies of highly selected populations in specific neurological-psychiatric (e.g. headaches and depression) and systemic diseases (e.g. diabetes mellitus).The results therefore will help to better understand the individual values in the context of diagnostic routine as well as in the further expanding field of neuroscience. Furthermore, it drives the development of neurophysiological and therapeutic approaches.