Asymmetric synthesis of polyols via transient hemiketals

在这个项目中，多元醇类结构将通过由前手性起始物质生成瞬时半缩酮来进行对映选择性的构建。形成新的C-O键的关键是瞬时半缩酮各自的稳定性，以及它的亲核性，这将在这个项目的过程中进行研究。在已有知识的基础上，我们的目标是探索催化剂来控制新形成的C-O键的对映和非对映选择性，并将已建立的分子复杂性用于特定的合成应用。

In this project, polyolic structures will be built enantioselectively via the formation of a transient hemiketal from prochiral starting materials. Crucial for the formation of novel C-O bonds is the respective stability of the transient hemiketal, as well as its nucleophilicity, which will be investigated over the course of this project. Building on the acquired knowledge, we aim to explore catalysts to control the enantio- and diastereoselectivity of the newly formed C-O bonds, and to use the established molecular complexity in specific synthetic applications.